[Effects of abnormal distribution of calcium on impairment of myocardial mechanics in the early stage of thermal injury].

L Chi, Z Yang, Y Huan
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引用次数: 0

Abstract

Objective: To investigate the effect of abnormal Ca2+ distribution on impairment of myocardial mechanics in the early stage of thermal injury.

Methods: Calcium (Ca2+) changes were observed within subcellular distribution in situ in rat heart with calcium cytochemical probe and electron probe microanalysic technique. Meanwhile, myocardial mechanics and energy metabolic changes were investigated after thermal injury.

Results: The results demonstrated that levels of cytoplasmic Ca2+ in cardiomyocytes increased at 1 hour, followed by enhanced mitochondrial Ca2+ at 3 hour after burn injury. Parallel to the changes in Ca2+, there were decrease of myocardial contraction, relaxation capacity and increase of ventricular wall stiffness in burned rats. A lower level of heart energy changes was observed from 6 to 12 hours, compared with control group.

Conclusion: The results indicate that subcellular Ca2+ abnormal distribution in myocardium caused by burn injury may be associated with rigor contraction and decreased relaxation of myocardium.

[钙异常分布对热损伤早期心肌力学损害的影响]。
目的:探讨钙离子分布异常对热损伤早期心肌力学损伤的影响。方法:采用钙细胞化学探针和电子探针显微分析技术,原位观察大鼠心脏亚细胞分布内钙(Ca2+)的变化。同时观察热损伤后心肌力学和能量代谢的变化。结果:结果表明,心肌细胞细胞质Ca2+水平在烧伤后1小时升高,随后在烧伤后3小时线粒体Ca2+水平升高。烧伤大鼠心肌收缩、舒张能力下降,心室壁僵硬度升高,Ca2+水平也随之改变。与对照组相比,在6至12小时内观察到较低水平的心脏能量变化。结论:烧伤引起的心肌亚细胞Ca2+分布异常可能与心肌收缩剧烈和舒张减少有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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