[The responses of fibroblasts from three parts of keloids and normal skin to interleukin-1 beta and interleukin-6].

Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns Pub Date : 1998-01-01

S Xu, Z Wang, W Bao

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Abstract

Objective: The purpose of this study was to explore the responses of fibroblasts from keloids and normal skin to interleukin-1 beta and interleukin-6.

Methods: Six samples of keloids and 6 samples of normal skin were collected as the experimental and control group respectively. The means of cell culture was used to investigate the responses of fibroblasts from three different parts of keloids and normal skin to interleukin-1 beta (200 U/ml) and interleukin-6 (100 U/ml).

Results: Interleukin-1 beta could inhibit the growth of fibroblasts from the proliferative part of keloids but stimulate growth of those from normal skin, while it did not affect the growth of those from other parts of keloids. Fibroblasts from different parts of keloids and normal skin were all inhibited by interleukin-6.

Conclusion: The responses of fibroblasts from three parts of keloids and normal skin to interleukin-1 beta and interleukin-6 were not much similar.

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[瘢痕疙瘩和正常皮肤三部分成纤维细胞对白细胞介素-1 β和白细胞介素-6的反应]。

目的:探讨瘢痕疙瘩和正常皮肤成纤维细胞对白细胞介素-1 β和白细胞介素-6的反应。方法:取瘢痕疙瘩6例，正常皮肤6例，分别作为实验组和对照组。采用细胞培养的方法，观察瘢痕疙瘩和正常皮肤3个不同部位成纤维细胞对白细胞介素-1 β (200 U/ml)和白细胞介素-6 (100 U/ml)的反应。结果:白细胞介素-1 β能抑制瘢痕疙瘩增生部位成纤维细胞的生长，刺激正常皮肤成纤维细胞的生长，而对瘢痕疙瘩其他部位成纤维细胞的生长无影响。来自瘢痕疙瘩不同部位和正常皮肤的成纤维细胞均受到白细胞介素-6的抑制。结论:瘢痕疙瘩和正常皮肤三部分成纤维细胞对白细胞介素-1 β和白细胞介素-6的反应不太相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns

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