What makes cells grow larger and how do they do it? Renal hypertrophy revisited.

P Preisig
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引用次数: 42

Abstract

Hypertrophy, defined as an increase in cell size without an increase in cell number, occurs in a number of conditions, including compensatory renal growth, diabetes mellitus, protein feeding, chronic metabolic acidosis, and chronic potassium deficiency. In vitro cell culture studies have been used to characterize the mechanisms involved in the development of hypertrophy. Two mechanisms have been identified and characterized. One mechanism involves regulation of processes that are also associated with the initial events of the hyperplastic growth process, and is referred as a cell cycle-dependent mechanism. The other mechanism occurs independently of these particular cell cycle processes, but involves regulation of protein degradation by lysosomal enzymes. This latter mechanism is referred to as a cell cycle-independent mechanism. In vivo studies suggest that both compensatory renal hypertrophy following uninephrectomy and diabetes mellitus-induced hypertrophy involve the cell cycle-dependent mechanism.

是什么让细胞变大,它们是如何做到的?再次发现肾肥大。
肥大,定义为细胞大小的增加而细胞数量的增加,发生在许多情况下,包括代偿性肾脏生长、糖尿病、蛋白质摄食、慢性代谢性酸中毒和慢性缺钾。体外细胞培养研究已被用来描述肥大发生的机制。已经确定并描述了两种机制。一种机制涉及与增生性生长过程的初始事件相关的过程的调节,被称为细胞周期依赖机制。另一种机制独立于这些特定的细胞周期过程,但涉及溶酶体酶对蛋白质降解的调节。后一种机制被称为细胞周期无关机制。体内研究表明,单肾切除术后代偿性肾肥大和糖尿病引起的肾肥大都涉及细胞周期依赖机制。
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