Urine free beta-human chorionic gonadotropin levels between 14 and 21 weeks of gestation in Taiwanese pregnancies.

Changgeng yi xue za zhi Pub Date : 1999-03-01

J J Hsu, T T Hsieh, T H Hung, K C Chen, Y K Soong

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Abstract

Background: The purpose of this study was to determine the reference range of maternal urine free beta-human chorionic gonadotropin (beta -hCG) concentrations between 14 and 21 weeks of gestation.

Methods: We measured the concentrations of urine free beta -hCG from 268 healthy singleton Taiwanese pregnancies between 14 and 21 weeks of gestation. Results were corrected for creatinine (Cr) concentration and converted to the multiple of the median (MOM) level for the appropriate gestation. Gestational ages of all cases were determined using ultrasound dating.

Results: The median levels of urine free beta -hCG and free beta-hCG/Cr had a downward trend in association with the increasing gestation age. The median, 5th, 10th, 90th and 95th centiles of free beta- hCG/Cr MOM values were 1.02, 0.20, 0.25, 2.32 and 3.38 MOM, respectively. Urine free beta- hCG/Cr MOM values showed a log Gaussian distribution with the mean and standard deviation (SD) distribution of -0.0657 and 0.3792, respectively.

Conclusion: To allow for differences in free beta -hCG/Cr median values at various ages of gestation, establishment of the reference range is essential for further development of maternal urine screening for Down syndrome.

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台湾妊娠14 ~ 21周游离尿β -人绒毛膜促性腺激素水平。

背景:本研究的目的是确定妊娠14 ~ 21周孕妇尿中游离β -人绒毛膜促性腺激素(β -hCG)浓度的参考范围。方法:对268例14 ~ 21周台湾健康单胎孕妇进行尿中游离β -hCG浓度测定。对结果进行肌酐(Cr)浓度校正，并转换为适合妊娠的中位数(MOM)水平的倍数。所有病例均采用超声测年法测定胎龄。结果:随着孕龄的增加，尿游离β -hCG和游离β -hCG/Cr中位数呈下降趋势。游离β - hCG/Cr的中位、第5、第10、第90和第95百分位的MOM值分别为1.02、0.20、0.25、2.32和3.38 MOM。尿游离β - hCG/Cr MOM值呈对数高斯分布，均值和标准差分别为-0.0657和0.3792。结论:为了考虑不同妊娠年龄游离β -hCG/Cr中值的差异，建立参考范围对于进一步开展唐氏综合征产妇尿液筛查至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Changgeng yi xue za zhi

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