{"title":"Role of APOE in dementia: A critical reappraisal.","authors":"P de Knijff, C M van Duijn","doi":"10.1159/000022430","DOIUrl":null,"url":null,"abstract":"<p><p>The apolipoprotein E (APOE) gene is strongly associated to the risk of Alzheimer's disease (AD). More specifically, it seems undisputed that the APOE*4 allele plays an important role in the pathogenesis of AD. However, does this imply that it is ApoE4 which causes the increased susceptibility for AD? Empirical findings in non-Caucasians leave space for at least one alternative hypothesis: not the ApoE4 polymorphism but other defects in, or close to the APOE gene, could be responsible. We discuss this hypothesis, based on population and evolutionary genetic evidence.</p>","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1998-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022430","citationCount":"18","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Haemostasis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000022430","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 18
Abstract
The apolipoprotein E (APOE) gene is strongly associated to the risk of Alzheimer's disease (AD). More specifically, it seems undisputed that the APOE*4 allele plays an important role in the pathogenesis of AD. However, does this imply that it is ApoE4 which causes the increased susceptibility for AD? Empirical findings in non-Caucasians leave space for at least one alternative hypothesis: not the ApoE4 polymorphism but other defects in, or close to the APOE gene, could be responsible. We discuss this hypothesis, based on population and evolutionary genetic evidence.
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