Molecular markers as prognostic factors for local recurrence and radioresistance in head and neck squamous cell carcinoma.

B D Smith, B G Haffty
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引用次数: 78

Abstract

Squamous cell carcinoma of the head and neck affects more than 500,000 people worldwide each year. Local-regional recurrence of disease is a common and challenging oncological problem in patients affected by this disease. Identification of risk factors for local relapse after appropriate local therapy with surgery, radiation, or combination therapy remains an active area of clinical research. The recent development of novel molecular markers has resulted in numerous studies evaluating the prognostic significance and potential clinical utility of these markers in identifying patients at risk for local-regional relapse. This article reviews recent studies evaluating molecular markers, including p53, angiogenesis-related markers, cyclin D1, epidermal growth factor receptor, loss of heterozygosity, DNA ploidy, and cell kinetic markers. The potential clinical utility of these markers and future directions along this avenue of investigation are discussed.

分子标志物作为头颈部鳞状细胞癌局部复发和放疗耐药的预后因素。
头颈部鳞状细胞癌每年影响全球50多万人。局部肿瘤复发是本病患者常见且具有挑战性的肿瘤问题。在适当的局部手术、放疗或联合治疗后局部复发的危险因素识别仍然是临床研究的一个活跃领域。最近新型分子标记物的发展导致了大量的研究,评估了这些标记物在识别局部区域复发风险患者中的预后意义和潜在的临床应用。本文综述了近年来评价分子标记的研究,包括p53、血管生成相关标记、细胞周期蛋白D1、表皮生长因子受体、杂合性缺失、DNA倍性和细胞动力学标记。这些标志物的潜在临床应用和未来的方向沿着这条研究途径进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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