Chemical characterization of silicon-substituted hydroxyapatite.

I R Gibson, S M Best, W Bonfield
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引用次数: 518

Abstract

Bioceramic specimens have been prepared by incorporating a small amount of silicon (0.4 wt %) into the structure of hydroxyapatite [Ca10(PO4)6(OH)2, HA] via an aqueous precipitation reaction to produce a silicon-substituted hydroxyapatite (Si-HA). The results of chemical analysis confirmed the proposed substitution of the silicon (or silicate) ion for the phosphorus (or phosphate) ion in hydroxyapatite. The Si-HA was produced by first preparing a silicon-substituted apatite (Si-Ap) by a precipitation process. A single-phase Si-HA was obtained by heating/calcining the as-prepared Si-Ap to temperatures above 700 degrees C; no secondary phases, such as tricalcium phosphate (TCP), tetracalcium phosphate (TeCP), or calcium oxide (CaO), were observed by X-ray diffraction analysis. Although the X-ray diffraction patterns of Si-HA and stoichiometric HA appeared to be identical, refinement of the diffraction data revealed some small structural differences between the two materials. The silicon substitution in the HA lattice resulted in a small decrease in the a axis and an increase in the c axis of the unit cell. This substitution also caused a decrease in the number of hydroxyl (OH) groups in the unit cell, which was expected from the proposed substitution mechanism. The incorporation of silicon in the HA lattice resulted in an increase in the distortion of the PO4 tetrahedra, indicated by an increase in the distortion index. Analysis of the Si-HA by Fourier transform infrared (FTIR) spectroscopy indicated that although the amount of silicon incorporated into the HA lattice was small, silicon substitution appeared to affect the FTIR spectra of HA, in particular the P-O vibrational bands. The results demonstrate that phase-pure silicon-substituted hydroxyapatite may be prepared using a simple precipitation technique.

硅取代羟基磷灰石的化学性质。
将少量硅(0.4 wt %)掺入羟基磷灰石[Ca10(PO4)6(OH)2, HA]的结构中,通过水相沉淀反应生成硅取代羟基磷灰石(Si-HA),制备了生物陶瓷样品。化学分析结果证实了羟基磷灰石中硅(或硅酸盐)离子取代磷(或磷酸盐)离子的提议。硅-羟基磷灰石是先用沉淀法制备硅取代磷灰石(Si-Ap)制备的。将制备的Si-Ap加热/煅烧至700℃以上,得到单相Si-HA;x射线衍射分析未观察到磷酸三钙(TCP)、磷酸四钙(TeCP)、氧化钙(CaO)等次生相。虽然Si-HA和化学计量HA的x射线衍射图看起来是相同的,但衍射数据的细化揭示了两种材料之间的一些小的结构差异。硅在HA晶格中的取代导致了单元胞的a轴的小幅度下降和c轴的增加。这种取代也导致了单位细胞中羟基(OH)基团数量的减少,这是根据所提出的取代机制所期望的。硅在羟基磷灰石晶格中的掺入导致PO4四面体的畸变增加,畸变指数增加。傅里叶变换红外光谱(FTIR)分析表明,虽然硅在HA晶格中的掺入量很少,但硅取代对HA的FTIR光谱,特别是P-O振动带有明显的影响。结果表明,采用简单的沉淀法可以制备相纯硅取代羟基磷灰石。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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