The voltammetric behavior of bone marrow of leukaemia and its clinical application

Bioelectrochemistry and bioenergetics (Lausanne, Switzerland) Pub Date : 1999-02-01 DOI:10.1016/S0302-4598(98)00218-9

Huai-Na Li , Yun-Xiang Ci , Jun Feng , Kang Cheng , Shuang Fu , De-Bing Wang

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引用次数: 29

Abstract

The electrochemical voltammetric behavior of bone marrow of leukaemia has been investigated by a self-devised cytosensing system. The two anodic peaks of erythrocytes (red blood cells, RBC) in bone marrow of leukaemia appeared at 0.73±0.03 and 0.83±0.02V vs. SCE, respectively, on the first scan. The anodic peak of leukocytes (white blood cells, WBC) appeared at 0.32±0.03V vs. SCE. The anodic peak of RBC at 0.83V disappeared when the patients were cured. The experimental results show that the voltammetric behavior of erythrocytes is in constant contact with the initial stage of leukaemia. The cyclic voltammetric behavior of 40 cases of leukaemia including acute myeloid leukaemia (AML) and chronic myeloid leukaemia (CML) and 10 cases of healthy volunteer peripheral blood was studied. The cyclic voltammetric behavior of erythrocytes may provide a simple and specific marker for diagnosis of leukaemia.

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白血病骨髓的伏安行为及其临床应用

用自行设计的细胞感应系统研究了白血病骨髓的电化学伏安行为。与SCE相比，白血病骨髓红细胞(红细胞、红细胞)第一次扫描出现两个阳极峰，分别为0.73±0.03 v和0.83±0.02V。与SCE相比，白细胞(白细胞，WBC)在0.32±0.03V出现阳极峰。红细胞在0.83V处的阳极峰在患者治愈后消失。实验结果表明，红细胞的伏安行为与白血病的初始阶段密切相关。本文研究了急性髓性白血病(AML)和慢性髓性白血病(CML)等40例白血病患者和10例健康志愿者外周血的循环伏安行为。红细胞的循环伏安行为可为白血病的诊断提供一种简单而特异的标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bioelectrochemistry and bioenergetics (Lausanne, Switzerland)

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