[The effect of the zinc-containing preparation Oxyrich in the treatment of chronic saturnism (preliminary results)].

Problemi na khigienata Pub Date : 1997-01-01
S Pavlova, V Petkova, Ch Nachev, D Georgieva, M Kerimova, I Khadzhieva
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Abstract

Under indoor conditions the effect of the Bulgarian zinc-containing preparation Oxyrich was studied in the treatment of 12 workers (males) with chronic saturnism. The preparation was orally administered in a dose of 150 mg (0.45 mmol Zn++) daily for 10 days in three equal receivings, after which three day antidotal therapy with CaNa2 EDTA was carried out according to the classic schedule. The complex investigation of the workers besides the clinical exmination included some key indices of the porphirine metabolism (5-ALK-D, 5-ALK, free protoporphirine in the red bolld cells), as well as the content of zinc and lead in the blood and their excretion with the urine prior and post the administration of Oxyrich and CaNa2 EDTA. The results of the carried out study revealed that the therapy with Oxyrich demonstrated a tendency to normalization of the activity of 5-ALK-D and decrease of the elimination of 5-ALK. This gave grounds for further study with higher doses of Oxyrich, as well as enlargement of the spectrum of the indices of the porphirine metabolism.

[含锌制剂富氧治疗慢性血湿的效果(初步结果)]。
在室内条件下,研究了保加利亚含锌制剂富氧(Oxyrich)对12名慢性农奴病工人(男性)的治疗效果。该制剂以150mg (0.45 mmol zzn ++)每日口服,分3次等量接受,连续10天,之后根据经典方案进行为期3天的CaNa2 EDTA解毒剂治疗。除临床检查外,对工人进行了复杂的调查,包括卟啉代谢的一些关键指标(红细胞中5-ALK- d、5-ALK、游离原卟啉),以及给氧和CaNa2 EDTA前后血液中锌、铅的含量及其随尿排出情况。所进行的研究结果显示,氧富治疗显示出5-ALK- d活性正常化和5-ALK消除减少的趋势。这为进一步研究高剂量的富氧,以及扩大卟啉代谢指数的谱提供了依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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