The effect of single shock waves on the vascular system of artificially perfused rabbit kidneys.

Abstract

Extracorporeally-perfused rabbit kidneys were exposed to five shock waves at 14 kV on the XL1 Dornier experimental lithotripter (Dornier Medical Systems, Inc., Germering, Germany). While the perfusion flow rate was kept constant, the arterial perfusion pressure was recorded to assess changes in vascular resistance. Immediately after shock wave application, perfusion pressure decreased by 20%-30%, followed by a short, relative pressure rise that did not reach pretreatment values. Fifteen-twenty minutes later, arterial perfusion pressure reattained pretreatment values. Subsequent to treatment, urine flow decreased by greater than 50%. The observed pressure rise was also induced in nontreated kidneys by perfusion with the effluent of treated kidneys indicating that this is based on a humoral mechanism. On the other hand, shock wave application to formalin fixed kidneys only caused a marked decrease in arterial perfusion pressure, suggesting that this effect is due to a pure mechanical interaction of the shock wave also found with denaturated kidneys. The observed decrease of urine flow is probably caused by a decreased filtration rate. Since this was not the case in nontreated kidneys being perfused with the effluent of treated kidneys, the reduction of urine flow after extracorporeal shock wave lithotripsy does not appear to be mediated by a humoral factor, but is more likely a result of the mechanically-induced vasodilation with consecutive decline of the glomerular filtration rate.