Antioxidant potential of cancerous human kidney tissues.

Cancer biochemistry biophysics Pub Date : 1998-10-01
H Biri, M Y Cimen, M Kaçmaz, S Büyükkoçak, I Sen, H S Oztürk, I Bozkirli, I Durak
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引用次数: 0

Abstract

Antioxidant potentials (AOP) of cancerous and noncancerous adjacent human kidney tissues from 12 patients were measured. AOP of the cancerous tissues was found to be significantly lower than that of noncancerous ones. However, tissue malondialdehyde (MDA) levels were significantly higher in the cancerous tissues compared with noncancerous ones. In the intra-correlation analysis, carried out between AOP and MDA levels, significant correlation was found in the cancerous tissues (r = 0.9) but no correlation observed in the noncancerous ones. In the inter-correlation analysis, negative correlation was found between AOP's of cancerous and noncancerous tissues (r = -0.49) and positive correlation between MDA levels (r = 0.51). Results suggest that antioxidant potential of cancerous kidney tissues is significantly reduced compared with noncancerous ones. Therefore, they expose to high oxidant stress and free radical-induced peroxidative attacks, the results of which are cellular deformations.

人类癌变肾组织的抗氧化潜能。
测定了12例癌旁和非癌旁肾组织的抗氧化电位(AOP)。癌组织的AOP明显低于非癌组织。然而,组织丙二醛(MDA)水平在癌组织中明显高于非癌组织。在AOP与MDA水平的相关分析中,癌组织中存在显著相关(r = 0.9),而非癌组织中无相关。在相关分析中,癌组织与非癌组织的AOP呈负相关(r = -0.49), MDA呈正相关(r = 0.51)。结果表明,与非癌肾组织相比,癌肾组织的抗氧化能力明显降低。因此,它们暴露于高氧化应激和自由基诱导的过氧化攻击,其结果是细胞变形。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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