Immunohematological study in newborn infants with erythroblastosis fetalis transfused in utero.

G Ancora, P Dallacasa, B Gavella, L Calderoni, S Nucci, D Belletti, N A Sorci, R Conte, G P Salvioli
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Abstract

The present study reports immunohematological data (anti-erythrocyte titer, anti-erythrocyte functional activity, percentage of sensitized erythrocytes) in 11 patients with erythroblastosis fetalis transfused in utero (IUTd). At birth it was possible to define two groups of newborns: one with low (group 1) and one with high (group 2) percentage of circulating sensitized erythrocytes, respectively. The presence of a low rate of sensitized red cells at birth in IUTd infants did not reduce the number of exchange transfusions required postnatally. On the contrary, babies of this group were affected by a more severe disease as shown by higher anti-erythrocyte maternal titer, higher anti-erythrocyte functional activity and a higher degree of fetal hemolysis. The persistence of hemolysis after birth, in spite of the absence of sensitized circulating erythrocytes, may be due to intramedullary hemolysis.

子宫内输注新生红细胞增多症胎儿的免疫血液学研究。
本研究报告了11例宫内输血(IUTd)的成红细胞症胎儿的免疫血液学数据(抗红细胞滴度、抗红细胞功能活性、致敏红细胞百分比)。在出生时,可以定义两组新生儿:一组低(组1)和一组高(组2)循环致敏红细胞百分比。宫内节育器婴儿出生时致敏红细胞率低并没有减少出生后所需的交换输血次数。相反,该组婴儿的疾病更为严重,表现为母体抗红细胞滴度较高,抗红细胞功能活性较高,胎儿溶血程度较高。出生后持续溶血,尽管没有致敏循环红细胞,可能是由于髓内溶血。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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