[Study of sorption properties of organosilanes to be used as the basis for hemosorbents and diagnostic enzyme and immunosensors].

Abstract

The abilities of different types of organosilanes, in particular of polymers with: 1) completely or 2) partially hydrophobical surfaces; 3) regular changes of part of silicium ions by metal ions; 4) preliminary aminosilanization were studied for sorption of ammonia ions, urea, cholesterol, creatinine, albumin, IgG, haemoglobin and myoglobin. Polymethylsiloxane was used as haemosorbent for directed sorption of myoglobin and haemoglobin from solution and blood. It didn't hemolysate red cells. The high efficiency of those organosilanes for sorption of haemoproteins it was shown. Organosilanes were very good as membrane for immobilization of urease and IgG-specific antibodies to create enzyme sensor and immunosensor based on the ionsensitive field effect transistors. The advantages and possibilities of organosilane usage as haemosorbents in the field of medicine of catastrophes as well as for sensor technology are discussed.