Clinical manifestations in the West Nile virus outbreak.

Romanian journal of virology Pub Date : 1997-01-01

E Ceauşu, S Erşcoiu, P Calistru, D Ispas, O Dorobăţ, M Homoş, C Bărbulescu, I Cojocaru, C V Simion, C Cristea, C Oprea, C Dumitrescu, D Duiculescu, I Marcu, C Mociorniţă, T Stoicev, I Zolotuşca, C Calomfirescu, R Rusu, R Hodrea, S Geamai, L Păun

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Abstract

During the summer of 1996 an unusual clustering of meningoencephalitis cases was recorded in the Capital City, Bucharest, and in some areas from South-East Romania. After an initial suspicion of an enteroviral etiology was discarded, the West Nile etiology was confirmed by specific antibodies demonstration through hemagglutination-inhibition and ELISA tests. This study included 251 patients with the diagnoses of West Nile acute encephalitis (166 cases), acute meningitis (57 cases) and acute febrile disease (33 cases). The patients' age ranged from 1 to 89 years (mean 51.1 years). The most frequent clinical manifestations were: fever (95.7% of cases), cephalalgia (92.6%), stiffness of the neck (89.1%), vomiting (62.5%), marked asthenia (46.5%), myalgia (28.9%). In addition, patients with encephalitis exhibited: alteration of consciousness (89.2% of cases), tremor of extremities (40.4%), ataxia (44%), paralysis (15.1%). The fatality rate was 15.1% in acute encephalitis, 1.8% in acute meningitis and 0% in the acute febrile disease.

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临床表现为西尼罗病毒暴发。

1996年夏季，在首都布加勒斯特和罗马尼亚东南部的一些地区记录了不寻常的脑膜脑炎聚集病例。在最初怀疑是肠道病毒病因后，西尼罗河病因通过血凝抑制和ELISA试验证实了特异性抗体。本研究纳入251例诊断为西尼罗急性脑炎(166例)、急性脑膜炎(57例)和急性发热病(33例)的患者。患者年龄1 ~ 89岁，平均51.1岁。最常见的临床表现为发热(95.7%)、头痛(92.6%)、颈部僵硬(89.1%)、呕吐(62.5%)、明显虚弱(46.5%)、肌痛(28.9%)。此外，脑炎患者表现为意识改变(89.2%)、四肢震颤(40.4%)、共济失调(44%)、瘫痪(15.1%)。急性脑炎病死率为15.1%，急性脑膜炎病死率为1.8%，急性温病病死率为0%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Romanian journal of virology

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