{"title":"Calcium-binding proteins and nitric oxide in retinal function and disease.","authors":"F Müller, K W Koch","doi":"10.1159/000046479","DOIUrl":null,"url":null,"abstract":"<p><p>Regulation of phototransduction in photoreceptor cells occurs via several feedback loops. Some of these circuits involve the neuron-specific Ca2+-binding proteins recoverin and guanylyl cyclase-activating protein. Recent findings suggest that these proteins are also involved in retinal diseases. Another Ca2+-regulated process in the retina is the synthesis of nitric oxide, a substance of potential neurotoxicity. This review discusses several Ca2+-mediated processes in the retina.</p>","PeriodicalId":6885,"journal":{"name":"Acta anatomica","volume":"162 2-3","pages":"142-50"},"PeriodicalIF":0.0000,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000046479","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta anatomica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000046479","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
Regulation of phototransduction in photoreceptor cells occurs via several feedback loops. Some of these circuits involve the neuron-specific Ca2+-binding proteins recoverin and guanylyl cyclase-activating protein. Recent findings suggest that these proteins are also involved in retinal diseases. Another Ca2+-regulated process in the retina is the synthesis of nitric oxide, a substance of potential neurotoxicity. This review discusses several Ca2+-mediated processes in the retina.
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