Absence of anti-beta2 glycoprotein I antibodies in giant cell arteritis: a study of 45 biopsy-proven cases.

British journal of rheumatology Pub Date : 1998-10-01 DOI:10.1093/rheumatology/37.10.1129

E Liozon, V Roussel, P Roblot, F Liozon, J L Preud'Homme, V Loustaud, E Vidal, M O Jauberteau

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引用次数: 27

Abstract

Objective: To search for a relationship between serum anti-beta2 glycoprotein I (anti-beta2GPI) antibodies and the occurrence of ischaemic complications in giant cell arteritis (GCA), since the latter do not correlate with anti-cardiolipin antibodies (ACL), which are frequently observed in GCA.

Methods: IgG and IgM anti-beta2GPI antibodies and ACL were measured by enzyme-linked immunosorbent assays in sera, collected before treatment, from 45 unselected patients with biopsy-proven GCA, including 15 patients with ischaemic events.

Results: IgG and IgM anti-beta2GPI antibodies were not detected in any of the patients, contrasting with the presence of ACL in 51%, of them, without correlation with ischaemia.

Conclusion: Anti-beta2GPI antibodies are not detectable in GCA, contrasting with the occurrence of ACL, and ischaemic complications are apparently unrelated to the most frequent anti-phospholipid antibodies.

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巨细胞动脉炎中缺乏抗β 2糖蛋白I抗体:45例活检证实病例的研究

目的:探讨血清抗β 2糖蛋白I (anti-beta2GPI)抗体与巨细胞动脉炎(GCA)缺血性并发症发生的关系，因为后者与GCA中常见的抗心磷脂抗体(ACL)无关。方法:采用酶联免疫吸附法测定治疗前收集的45例活检证实的GCA患者血清中的IgG、IgM抗β 2gpi抗体和ACL，其中包括15例有缺血事件的患者。结果:所有患者均未检出IgG和IgM抗β 2gpi抗体，51%患者存在ACL，与缺血无相关性。结论:与ACL的发生相比，GCA中未检出抗β - 2gpi抗体，而缺血性并发症与最常见的抗磷脂抗体明显无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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British journal of rheumatology

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