Phenotypic analysis of PBMCs from uterine cervix cancer patients with high natural killer activity.

Abstract

Phenotypic analysis of peripheral blood mononuclear cells from uterine cervix cancer patients, with increased natural killer cell activity, treated with radiation therapy was carried out. An increase in the percentage of CD56+ cells was observed in 5 out of 7 patients. When the expression of CD69, a phenotypic marker of cellular activation, was analyzed in 6 patients, an increase was observed in 4 of them. No direct correlation between cytolytic activity and the levels of CD56+ or CD69+ cells were observed. After 72 hr, an increased expression of CD56 was observed in 3 patients and a similar picture was seen at the same time following activation with IL-2 or IFN.