The differential miscibility of lipids as the basis for the formation of functional membrane rafts

Anton Rietveld, Kai Simons
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引用次数: 496

Abstract

The formation of sphingolipid-cholesterol microdomains in cellular membranes has been proposed to function in sorting and transport of lipids and proteins as well as in signal transduction. An increasing number of cell biological and biochemical studies now supports this concept. Here we discuss the structural properties of lipids in a cell biological context. The sphingolipid-cholesterol microdomains or rafts are described as dispersed liquid ordered phase domains. These domains are dynamic assemblies to which specific proteins are selectively sequestered while others are excluded. The proteins associated to rafts can act as organizers and can modulate raft size and function.

脂质的不同混溶性是形成功能性膜筏的基础
鞘脂-胆固醇微结构域在细胞膜上的形成被认为在脂质和蛋白质的分类和运输以及信号转导中起作用。越来越多的细胞生物学和生物化学研究现在支持这一概念。在这里,我们讨论脂质在细胞生物学背景下的结构特性。鞘脂-胆固醇微结构域或筏被描述为分散的液体有序相结构域。这些结构域是动态组装,特定的蛋白质被选择性地隔离在其中,而其他蛋白质被排除在外。与木筏相关的蛋白质可以作为组织者,可以调节木筏的大小和功能。
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