Cholesterol synthesis is increased in mixed hyperlipidaemia

R.P. Naoumova , K.-D. Kim , C. Neuwirth , S. Niththyananthan , N.B. Rendell , G.W. Taylor , G.R. Thompson
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引用次数: 3

Abstract

We showed previously that hypertriglyceridaemia, but not hypercholesterolaemia, is correlated with increases in cholesterol synthesis and apolipoprotein B secretion in patients with secondary hypertriglyceridaemia. The aim of the present study was to compare the rate of cholesterol synthesis, using fasting plasma mevalonic acid (MVA) as an index, in patients with primary mixed hyperlipidaemia (type IIb phenotype, n=45) and primary hypercholesterolaemia (type IIa phenotype, n=92). LDL cholesterol was significantly higher in types IIa (6.38±0.18 mmol/l) and IIb (5.89±0.25 mmol/l) compared to 40 normolipidaemic controls (2.99±0.1 mmol/l, P<0.0001), whereas serum triglyceride was higher in type IIb (2.62 (range 2.2–3.0) mmol/l) than type IIa (1.22 (range 0.85–1.60) mmol/l, P<0.001) and controls (0.90 (range 0.68–1.24) mmol/l, P<0.001). Similarly, MVA was higher in type IIb (7.0±0.46 ng/ml) than IIa (5.6±0.23 ng/ml, P<0.0) and controls (5.6±0.36 ng/ml, P<0.05). Plasma MVA correlated positively with serum triglyceride (r=0.22, P=0.004) and negatively with LDL cholesterol (r=−0.21, P=0.014). These results are in accordance with previous observations that VLDL-apolipoprotein B secretion and cholesterol synthesis are linked and demonstrate that the latter is increased in mixed hyperlipidaemia.

混合性高脂血症中胆固醇合成增加
我们之前的研究表明,继发性高甘油三酯血症患者的胆固醇合成和载脂蛋白B分泌增加与高甘油三酯血症相关,而与高胆固醇血症无关。本研究的目的是比较原发性混合型高脂血症(IIb型,n=45)和原发性高胆固醇血症(IIa型,n=92)患者空腹血浆甲羟戊酸(MVA)作为指标的胆固醇合成率。低密度脂蛋白胆固醇在IIa型(6.38±0.18 mmol/l)和IIb型(5.89±0.25 mmol/l)显著高于40例正常血脂对照组(2.99±0.1 mmol/l, P<0.0001),而血清甘油三酯在IIb型(2.62(范围2.2-3.0)mmol/l)高于IIa型(1.22(范围0.85-1.60)mmol/l, P<0.001)和对照组(0.90(范围0.68-1.24)mmol/l, P<0.001)。同样,IIb型MVA(7.0±0.46 ng/ml)高于IIa型(5.6±0.23 ng/ml, P<0.0)和对照组(5.6±0.36 ng/ml, P<0.05)。血浆MVA与血清甘油三酯呈正相关(r=0.22, P=0.004),与LDL胆固醇呈负相关(r= - 0.21, P=0.014)。这些结果与先前的观察一致,即vldl -载脂蛋白B分泌与胆固醇合成有关,并表明后者在混合性高脂血症中增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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