Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3.

K E White, M J Econs
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引用次数: 4

Abstract

A novel gene, PiUS, was recently cloned and shown to increase phosphate uptake when expressed in oocytes, indicating that it may be an important regulator of cellular phosphate homeostasis. The phosphate wasting disease autosomal dominant hypophosphatemic rickets (ADHR) was previously mapped to chromosome 12p13 by linkage analysis. PiUS' role as a modulator of phosphate transport, as well as its intestinal and renal expression made the gene an appropriate candidate for ADHR. The purpose of our study was to determine the chromosomal localization of the human PiUS gene through the use of somatic cell hybrids and radiation hybrid mapping. In the present work, PiUS was localized to human chromosome 3p21.3 and is therefore not the ADHR gene.

人类染色体3p21.3细胞磷酸摄取刺激物PiUS的定位。
一个新的基因,PiUS,最近被克隆出来,并显示在卵母细胞中表达时增加磷酸盐摄取,表明它可能是细胞磷酸盐稳态的重要调节因子。磷酸消耗病常染色体显性低磷血症佝偻病(ADHR)先前通过连锁分析定位于染色体12p13。PiUS作为磷酸盐转运调节剂的作用,以及它在肠道和肾脏的表达,使其成为ADHR的合适候选基因。我们研究的目的是通过体细胞杂交和辐射杂交作图来确定人类PiUS基因的染色体定位。在本研究中,PiUS定位于人类染色体3p21.3,因此不是ADHR基因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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