Susceptibility of avian mycoplasmas isolated in Taiwan to 21 antimicrobial agents.

M Y Lin, Y C Chiang, K Y Lin, H T Sung
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Abstract

Twenty-one antimicrobial agents were incorporated individually into Frey's agar to evaluate their inhibitory activities against 86 isolates of avian mycoplasmas recently detected in Taiwan. Among them, 45 and 37 isolates were found positive with Mycoplasma gallisepticum and Mycoplasma synoviae fluorescent antibody conjugate, respectively. Twenty-one other isolates were unable to be identified by the above 2 conjugates. All of the field isolates were highly sensitive (with MIC50 < 1 microgram/ml) to enrofloxacin, gentamicin, myplabin, tiamutin and tylosin. However, those field isolates were highly resistant (with MIC50 > 32 micrograms/ml) to apramycin, chlortetracycline (CTC), erythromycin (ER), flumequine (FI), nalidixic acid (NA), oxolinic acid (OA), oxytetracycline (OTC) and spiramycin (SP). The inhibitory activities of the antibiotics which possessed an MIC90 of 50 micrograms/ml or less against local isolates were, in decreasing order, enrofloxacin (< 0.004 microgram/ml), gentamicin (1.53 micrograms/ml), tiamutin (1.81 micrograms/ml), tylosin (3.2 micrograms/ml), streptomycin (SM; 12.0 micrograms/ml), colistin (13.1 micrograms/ml), chloramphenicol (14.0 micrograms/ml), spectinomycin (15.0 micrograms/ml), myplabin (16.0 micrograms/ml), spiramycin (30.0 micrograms/ml), minocycline (32.0 micrograms/ml). The MIC90 of OA, CTC, SM, FI, SP, OTC, ER or NA was greater than 50 micrograms/ml; which work poorly in the control of mycoplasmoses. Since the antibiotic control policy is quite loose in Taiwan, many antimicrobial agents are often freely used in clinics, with a resulting gradual decrease in the inhibitory activity to the avian mycoplasmas.

台湾地区禽支原体对21种抗菌药物的敏感性分析。
本文将21种抗菌药物分别加入到Frey’s琼脂中,对台湾地区最近检测到的86株禽支原体进行抑菌活性评价。其中鸡败支原体荧光抗体阳性45株,滑膜支原体荧光抗体阳性37株。另外21株分离物无法通过上述2种结合物进行鉴定。所有野外分离株对恩诺沙星、庆大霉素、myplabin、tiamutin和tylosin高度敏感(MIC50 < 1微克/ml)。但对阿帕霉素、氯霉素(CTC)、红霉素(ER)、氟喹(FI)、萘啶酸(NA)、草酸(OA)、土霉素(OTC)和螺旋霉素(SP)具有高度耐药(MIC50 > 32微克/ml)。MIC90≤50微克/ml的抗生素对本地分离菌的抑制活性依次为恩诺沙星(< 0.004微克/ml)、庆大霉素(1.53微克/ml)、替阿穆汀(1.81微克/ml)、泰洛辛(3.2微克/ml)、链霉素(SM;12.0微克/毫升)、粘菌素(13.1微克/毫升)、氯霉素(14.0微克/毫升)、大观霉素(15.0微克/毫升)、myplabin(16.0微克/毫升)、螺旋霉素(30.0微克/毫升)、米诺环素(32.0微克/毫升)。OA、CTC、SM、FI、SP、OTC、ER、NA的MIC90均大于50微克/ml;在控制支原体方面效果很差。由于台湾的抗生素管制政策相当宽松,许多抗菌药物在诊所经常被随意使用,导致对禽支原体的抑制活性逐渐下降。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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