{"title":"Evaluation of membranous staining of mesothelioma.","authors":"J A King, J A Tucker","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Panels of immunohistochemical markers are often used to aid in categorizing malignant neoplasms involving the pleura. While epithelial membrane antigen (EMA) and human milk fat globule-2 (HMFG-2) are each reported to stain the majority of cases of adenocarcinoma and mesothelioma, authors have reported that the pattern of staining for these two antibodies can be a useful discriminant. Both are described as revealing a membranous pattern of staining for mesothelioma and a cytoplasmic staining pattern in adenocarcinoma. Immunostains were performed on 23 cases of malignant mesothelioma and 22 cases of adenocarcinoma. For EMA, 78% of mesotheliomas and 86% of adenocarcinomas stained positively, and 65% of mesotheliomas vs. 14% of adenocarcinomas exhibited a membranous staining pattern. For HMFG-2, 9% of mesotheliomas and 50% of adenocarcinomas stained positively, and 4% of mesotheliomas vs. 9% of adenocarcinomas exhibited a membranous staining pattern. Membranous staining for HMFG-2 was not a useful criterion. In this series, a membranous pattern of staining for EMA had a sensitivity of 65% and a specificity of 86% for the identification of malignant mesothelioma.</p>","PeriodicalId":79574,"journal":{"name":"Cell vision : the journal of analytical morphology","volume":"5 1","pages":"24-7"},"PeriodicalIF":0.0000,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell vision : the journal of analytical morphology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Panels of immunohistochemical markers are often used to aid in categorizing malignant neoplasms involving the pleura. While epithelial membrane antigen (EMA) and human milk fat globule-2 (HMFG-2) are each reported to stain the majority of cases of adenocarcinoma and mesothelioma, authors have reported that the pattern of staining for these two antibodies can be a useful discriminant. Both are described as revealing a membranous pattern of staining for mesothelioma and a cytoplasmic staining pattern in adenocarcinoma. Immunostains were performed on 23 cases of malignant mesothelioma and 22 cases of adenocarcinoma. For EMA, 78% of mesotheliomas and 86% of adenocarcinomas stained positively, and 65% of mesotheliomas vs. 14% of adenocarcinomas exhibited a membranous staining pattern. For HMFG-2, 9% of mesotheliomas and 50% of adenocarcinomas stained positively, and 4% of mesotheliomas vs. 9% of adenocarcinomas exhibited a membranous staining pattern. Membranous staining for HMFG-2 was not a useful criterion. In this series, a membranous pattern of staining for EMA had a sensitivity of 65% and a specificity of 86% for the identification of malignant mesothelioma.