Evaluation of membranous staining of mesothelioma.

J A King, J A Tucker
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Abstract

Panels of immunohistochemical markers are often used to aid in categorizing malignant neoplasms involving the pleura. While epithelial membrane antigen (EMA) and human milk fat globule-2 (HMFG-2) are each reported to stain the majority of cases of adenocarcinoma and mesothelioma, authors have reported that the pattern of staining for these two antibodies can be a useful discriminant. Both are described as revealing a membranous pattern of staining for mesothelioma and a cytoplasmic staining pattern in adenocarcinoma. Immunostains were performed on 23 cases of malignant mesothelioma and 22 cases of adenocarcinoma. For EMA, 78% of mesotheliomas and 86% of adenocarcinomas stained positively, and 65% of mesotheliomas vs. 14% of adenocarcinomas exhibited a membranous staining pattern. For HMFG-2, 9% of mesotheliomas and 50% of adenocarcinomas stained positively, and 4% of mesotheliomas vs. 9% of adenocarcinomas exhibited a membranous staining pattern. Membranous staining for HMFG-2 was not a useful criterion. In this series, a membranous pattern of staining for EMA had a sensitivity of 65% and a specificity of 86% for the identification of malignant mesothelioma.

间皮瘤膜性染色的评价。
免疫组化标记常用于帮助分类累及胸膜的恶性肿瘤。虽然上皮膜抗原(EMA)和人乳脂球-2 (HMFG-2)分别被报道染色大多数腺癌和间皮瘤病例,作者已经报道,这两种抗体的染色模式可以是一个有用的鉴别。两者均表现为间皮瘤的膜性染色和腺癌的细胞质染色。对23例恶性间皮瘤和22例腺癌进行免疫染色。对于EMA, 78%的间皮瘤和86%的腺癌呈阳性染色,65%的间皮瘤和14%的腺癌呈膜性染色模式。对于HMFG-2, 9%的间皮瘤和50%的腺癌呈阳性染色,4%的间皮瘤和9%的腺癌呈膜样染色。HMFG-2的膜染色不是一个有用的标准。在这个系列中,EMA的膜性染色模式识别恶性间皮瘤的敏感性为65%,特异性为86%。
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