Effect of Aging on Experimental Autoimmune Prostatitis: Differential Kinetics of Development

Clinical immunology and immunopathology Pub Date : 1998-06-01 DOI:10.1006/clin.1998.4534

Gabriel Morón, Belkys Maletto, Andrea Rópolo, Marı́a Cristina Pistoresi-Palencia

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引用次数: 10

Abstract

We have studied the influence of aging on the kinetics of autoimmune response in Experimental Autoimmune Prostatitis (EAP). EAP was induced in 3- and 12-month-old Wistar rats by i.d. immunization with a saline extract of rat male sex accesory glands (RAG), chemically modified, and emulsioned in CFA. After immunization, 12-month-old rats developed a faster and stronger specific DTH response against RAG and mononuclear infiltration in the prostate. The levels of total IgM and IgG against RAG were lower in 12-month-old rats than in 3-month-old rats, with a prevalence of IgG2a, IgG2b, and IgG2c subclasses in both ages. Immunization stimulated slightly the appearance of specific IgG1 to RAG only in 3-month-old rats but in 12-month-old rats there was no specific IgG1 to RAG. On the other hand, normal 12-month-old rats showed higher levels of some natural antibodies and their thymocytes and peripheral lymphocytes had a diminished proliferative capacity compared to 3-month-old rats. These data demonstrated that 12-month-old rats show parameters of an aged immune system and present an exacerbated autoimmune prostatitis compared with 3-month-old rats.

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衰老对实验性自身免疫性前列腺炎的影响:发展的差异动力学

我们研究了衰老对实验性自身免疫性前列腺炎(Experimental autoimmune Prostatitis, EAP)自身免疫反应动力学的影响。用大鼠雄性性腺(RAG)生理盐水提取物，经化学修饰，在CFA中乳化，免疫诱导3月龄和12月龄Wistar大鼠EAP。免疫后，12月龄大鼠对RAG和前列腺单核浸润产生更快、更强的特异性DTH反应。12月龄大鼠抗RAG的IgM和IgG总水平低于3月龄大鼠，两个年龄的大鼠均存在IgG2a、IgG2b和IgG2c亚类。免疫仅在3月龄大鼠中轻微刺激RAG特异性IgG1的出现，而在12月龄大鼠中没有针对RAG的特异性IgG1。另一方面，与3个月大的大鼠相比，12个月大的正常大鼠的某些天然抗体水平较高，胸腺细胞和外周血淋巴细胞的增殖能力减弱。这些数据表明，与3个月大鼠相比，12个月大鼠表现出衰老的免疫系统参数，并表现出加重的自身免疫性前列腺炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical immunology and immunopathology

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