[Beta 2-microglobulin as a criterion of dysfunction in the regulation of proximal tubular activity in mercuric chloride-induced nephropathy].

Abstract

Sublimate nephropathy--modelled pathology of proximal nephron--serves as illustration of a pathogenetic role in development of proximal tubular dysfunction of enhanced vasoconstrictive potential of angiotensin II in plasma, angiotensin II and thromboxane B2 in renal cortex. The multiple regression equation has been calculated. The proportional contribution of plasma angiotensin II, atrial natriuretic peptide of plasma, cortical angiotensin II, cortical thromboxane B2 to regulation of proximal nephron function was the following: 26.85, 32.72, 10.51 and 10.56%, respectively.