Liver bilirubin UDP-glucuronosyltransferase activity in chronic nonhemolytic unconjugated hyperbilirubinemia of adults.

Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie Pub Date : 1998-04-01 DOI:10.1007/s004330050081

A Watanabe, H Wakabayashi, Y Kuwabara, H Yamamoto, S Hattori, T Tsuji

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引用次数: 2

Abstract

Ten adult patients with chronic nonhemolytic unconjugated (indirect) hyperbilirubinemia were analyzed by determining bilirubin uridine diphosphate-glucuronosyltransferase activity according to a more physiological and sensitive method (9 control cases, 0.457 +/- 0.163 nmole/mg protein/min). There was no overlap of the enzyme activities of 2 cases with Crigler-Najjar syndrome (type II) (0.006 nmole/mg protein/min on average) and 6 cases with Gilbert's syndrome (0.051 +/- 0.016 nmole/mg protein/min). The enzyme activities in 2 patients with post-hepatitic hyperbilirubinemia were within the normal range. A new classification of nonhemolytic unconjugated hyperbilirubinemia in adults is proposed according to the results of this enzyme activity and the recent data on the gene mutation of this enzyme.

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成人慢性非溶血性非结合性高胆红素血症的肝胆红素udp -糖醛酸糖基转移酶活性。

对10例成人慢性非溶血性非偶联(间接)高胆红素血症患者采用生理灵敏的方法测定胆红素尿苷二磷酸-葡萄糖醛酸糖基转移酶活性(对照9例，0.457 +/- 0.163 nmol /mg蛋白/min)。2例Crigler-Najjar综合征(II型)(平均0.006 nmol /mg蛋白/min)和6例Gilbert综合征(0.051 +/- 0.016 nmol /mg蛋白/min)的酶活性无重叠。2例肝后高胆红素血症患者酶活性均在正常范围内。根据该酶活性的结果和该酶基因突变的最新数据，提出了成人非溶血性非结合性高胆红素血症的新分类。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie

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