‘Endocannabinoids’ and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance

Vincenzo Di Marzo
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引用次数: 128

Abstract

The only endogenous substances isolated and characterised so far that are capable of mimicking the pharmacological actions of the active principle of marijuana, (−)-Δ9-tetrahydrocannabinol, are amides and esters of fatty acids. Some of these compounds, like anandamide (N-arachidonoylethanolamine) and 2-arachidonoylglycerol, act as true ‘endogenous cannabinoids’ by binding and functionally activating one or both cannabinoid receptor subtypes present on nervous and peripheral cell membranes. The metabolic pathways and molecular mode of actions of these metabolites, as well as their possible implication in physiopathological responses, are reviewed here.

“内源性大麻素”和其他具有大麻模拟特性的脂肪酸衍生物:生物化学和可能的生理病理相关性
迄今为止,唯一分离和表征的内源性物质能够模仿大麻的活性原理(−)-Δ9-tetrahydrocannabinol的药理作用,是脂肪酸的酰胺和酯。其中一些化合物,如anandamide (n -花生四烯醇乙醇胺)和2-花生四烯醇甘油,通过结合和功能激活存在于神经和外周细胞膜上的一种或两种大麻素受体亚型,充当真正的“内源性大麻素”。本文综述了这些代谢物的代谢途径和作用的分子模式,以及它们在生理病理反应中的可能意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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