XDOM, a graphical tool to analyse domain arrangements in any set of protein sequences.

Computer applications in the biosciences : CABIOS Pub Date : 1997-12-01 DOI:10.1093/bioinformatics/13.6.601

J Gouzy, P Eugéne, E A Greene, D Kahn, F Corpet

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引用次数: 30

Abstract

Motivation: To extract the maximum possible information from a set of protein sequences, its modular organization must be known and clearly displayed. This is important both for structural and functional analysis.

Results: This paper presents an algorithm and a graphical interface called XDOM which performs a systematic analysis of the modular organization of any set of protein sequences. The algorithm is an automatic method to identify putative domains from sequence comparisons. The graphical tool displays the proteins as a set of linked boxes, corresponding to its domains. The method has been tested on a family of bacterial proteins and on whole genomes. It is currently applied to the complete SWISS-PROT database to build the PRODOM database.

Availability: XDOM is available free of charge by anonymous ftp:¿¿ftp://ftp.toulouse.inra.fr/pub/xdom¿ ¿. The ProDom database can be consulted at ¿¿http://protein.toulouse.inra.fr/prodom.html¿¿.

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XDOM是一种图形化工具，用于分析任何一组蛋白质序列中的结构域排列。

动机:为了从一组蛋白质序列中提取最大可能的信息，必须知道并清楚地显示其模块化组织。这对于结构和功能分析都很重要。结果:本文提出了一种算法和图形界面XDOM，可以对任意一组蛋白质序列的模块化组织进行系统分析。该算法是一种从序列比较中自动识别假定域的方法。图形工具将蛋白质显示为一组链接框，对应于其域。该方法已经在一个细菌蛋白质家族和整个基因组上进行了测试。目前应用于完整的SWISS-PROT数据库，构建PRODOM数据库。可用性:XDOM可以通过匿名ftp免费获得:¿¿ftp://ftp.toulouse.inra.fr/pub/xdom¿¿。ProDom数据库可以在¿¿http://protein.toulouse.inra.fr/prodom.html¿¿上查询。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Computer applications in the biosciences : CABIOS

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