Surgical treatment of hepatic hydatidosis combined with perioperative treatment with albendazole.

A G Türkçapar, S Ersöz, C Güngör, K Aydinuraz, M A Yerdel, N Aras
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Abstract

Objective: To evaluate the effect of albendazole combined with surgery on the incidence of recurrent hydatid disease.

Design: Prospective open study.

Setting: Teaching hospital, Turkey.

Subjects: 25 patients who presented with hepatic hydatid disease between December 1992 and October 1995.

Interventions: Albendazole 10 mg/kg/day for a month before ultrasonography and then excision, and then albendazole for a further two months.

Results: 2 patients were excluded because the albendazole caused disturbance of liver enzyme activities. Of the remaining 23 patients only 7 had viable cysts on ultrasonography. In 15 patients (65%) the germinal layer was partially or totally destroyed, and in 15 the fluid was either cloudy or stained with bile. During a mean follow up period of 29 months only one patient developed recurrent disease.

Conclusion: Perioperative treatment with albendazole resulted in fewer recurrences than expected. A longer preoperative period of treatment may increase the success rate; this requires further study.

肝包虫病的外科治疗联合阿苯达唑围手术期治疗。
目的:评价阿苯达唑联合手术治疗对复发包虫病发病率的影响。设计:前瞻性开放式研究。地点:土耳其教学医院。对象:1992年12月至1995年10月期间出现肝包虫病的25例患者。干预措施:阿苯达唑10mg /kg/天用药1个月,超声检查后切除,再加阿苯达唑用药2个月。结果:2例患者因阿苯达唑引起肝酶活性紊乱而被排除。在其余23例患者中,超声检查显示仅有7例囊肿存活。15例(65%)患者生发层部分或完全破坏,15例液体混浊或胆汁染色。平均随访期间开发的29个月只有一个病人复发性疾病。结论:阿苯达唑围手术期治疗的复发率低于预期。较长的术前治疗期可提高成功率;这需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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