A G Türkçapar, S Ersöz, C Güngör, K Aydinuraz, M A Yerdel, N Aras
{"title":"Surgical treatment of hepatic hydatidosis combined with perioperative treatment with albendazole.","authors":"A G Türkçapar, S Ersöz, C Güngör, K Aydinuraz, M A Yerdel, N Aras","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of albendazole combined with surgery on the incidence of recurrent hydatid disease.</p><p><strong>Design: </strong>Prospective open study.</p><p><strong>Setting: </strong>Teaching hospital, Turkey.</p><p><strong>Subjects: </strong>25 patients who presented with hepatic hydatid disease between December 1992 and October 1995.</p><p><strong>Interventions: </strong>Albendazole 10 mg/kg/day for a month before ultrasonography and then excision, and then albendazole for a further two months.</p><p><strong>Results: </strong>2 patients were excluded because the albendazole caused disturbance of liver enzyme activities. Of the remaining 23 patients only 7 had viable cysts on ultrasonography. In 15 patients (65%) the germinal layer was partially or totally destroyed, and in 15 the fluid was either cloudy or stained with bile. During a mean follow up period of 29 months only one patient developed recurrent disease.</p><p><strong>Conclusion: </strong>Perioperative treatment with albendazole resulted in fewer recurrences than expected. A longer preoperative period of treatment may increase the success rate; this requires further study.</p>","PeriodicalId":22411,"journal":{"name":"The European journal of surgery = Acta chirurgica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1997-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The European journal of surgery = Acta chirurgica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: To evaluate the effect of albendazole combined with surgery on the incidence of recurrent hydatid disease.
Design: Prospective open study.
Setting: Teaching hospital, Turkey.
Subjects: 25 patients who presented with hepatic hydatid disease between December 1992 and October 1995.
Interventions: Albendazole 10 mg/kg/day for a month before ultrasonography and then excision, and then albendazole for a further two months.
Results: 2 patients were excluded because the albendazole caused disturbance of liver enzyme activities. Of the remaining 23 patients only 7 had viable cysts on ultrasonography. In 15 patients (65%) the germinal layer was partially or totally destroyed, and in 15 the fluid was either cloudy or stained with bile. During a mean follow up period of 29 months only one patient developed recurrent disease.
Conclusion: Perioperative treatment with albendazole resulted in fewer recurrences than expected. A longer preoperative period of treatment may increase the success rate; this requires further study.