Diagnosis of Pfiesteria-human illness syndrome.

R C Shoemaker
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Abstract

The first case reports of human illness caused by exposure to Pfiesteria piscicida toxin(s) acquired outside of a laboratory are reported. Though Pfiesteria, a toxin-forming dinoflagellate, is responsible for killing billions of fish in estuaries in North Carolina, its role in human illness has remained controversial, in part due to lack of identification of the toxin. A recent fish kill in the rivers of the lower Eastern Shore has permitted careful investigation and identification of a distinct clinical syndrome resulting from exposure to the Pfiesteria toxin--Pfiesteria human illness syndrome (PHIS). Patients have memory losses, cognitive impairments, headaches, skin rashes, abdominal pain, secretory diarrhea, conjunctival irritation, and bronchospasm. Not all patients have all elements of the syndrome.

猪瘟-人病综合征的诊断。
报告了在实验室以外获得的由暴露于鱼毒Pfiesteria piscicida毒素引起的人类疾病的第一例报告。尽管一种有毒的鞭毛藻(Pfiesteria)杀死了北卡罗来纳州河口的数十亿条鱼,但它在人类疾病中的作用仍然存在争议,部分原因是缺乏对这种毒素的鉴定。最近在东岸下游河流中发生的一次鱼类死亡事件,使人们得以仔细调查和确定一种因接触Pfiesteria毒素而引起的独特临床综合征——Pfiesteria人类疾病综合征(PHIS)。患者有记忆丧失、认知障碍、头痛、皮疹、腹痛、分泌性腹泻、结膜刺激和支气管痉挛。并不是所有的病人都有这种综合症的所有症状。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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