Collagen gene expression in the neomatrix of carcinoma of the breast.

Invasion & metastasis Pub Date : 1996-01-01
I L Wapnir, H Southard, G Chen, J Friedman, C D Boyd, P S Amenta
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引用次数: 0

Abstract

Excessive deposition of extracellular matrix or neomatrix is a characteristic of desmoplastic invasive breast carcinomas. Type I and III collagens are abundant neomatrix components. Archival breast tissue sections were studied using 35S-labeled cDNA probes for alpha 1(I) and alpha 1(III) procollagen and in situ hybridization. Among the 33 invasive breast cancers, hybridization was seen forming a gradient-like pattern in fibroblasts closest to tumor cells. In the 10 ductal carcinomas in situ studied, a ring-like pattern of hybridization was seen in proximity to the basement membrane zone. Adjacent normal and benign tissues did not demonstrate the patterns of hybridization described in malignant tissues. Gene expression for neomatrix interstitial collagens occurs before there is evidence of invasion in carcinoma of the breast.

胶原基因在乳腺癌新基质中的表达。
细胞外基质或新基质的过度沉积是侵袭性结缔组织增生乳腺癌的特征。I型和III型胶原是丰富的新基质成分。使用35s标记的cDNA探针对α 1(I)和α 1(III)前胶原进行原位杂交。在33例浸润性乳腺癌中,杂交在最靠近肿瘤细胞的成纤维细胞中形成梯度样模式。在原位研究的10例导管癌中,基膜区附近可见环状杂交模式。邻近的正常和良性组织没有表现出恶性组织中描述的杂交模式。新基质间质胶原的基因表达发生在有证据表明乳腺癌浸润之前。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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