Selection and performance of the levonorgestrel-releasing intrauterine system.

P Lähteenmäki, C W Bardin, K Elomaa, M Haukkamaa, A Kivijärvi, A Kuukankorpi, M Venhola, J Tuominen
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Abstract

Background: The levonorgestrel-releasing intrauterine system (LNg IUS) is a hormonal contraceptive that is used in the uterine cavity. To determine whether the reasons for choosing LNg IUS vs. copperreleasing intrauterine devices (Cu IUDs) differ and whether their performances are comparable, we carried out a retrospective study in Finland during the first years of LNg IUS use.

Methods: Gynecological and contraceptive histories of 626 LNg IUS and 626 Cu IUD users and the performance of the device were reviewed from patient records.

Results: Women who accepted the LNg IUS were more likely than Cu IUD acceptors to have a history of menstrual bleeding of 6 days or more (44.4% vs. 28.4%), heavy bleeding (44.8% vs. 8.4%) and moderate or severe dysmenorrhea (15.9% vs. 7.5%). In both groups, 70% of the women had used Cu IUDs earlier. However, the LNg IUS acceptors had had more side effects during previous use of CU IUDs (58.2% vs. 28.8%). They also reported more side effects that resulted in discontinuation of a previous Cu IUD (39.4% vs. 10.1%). However, the 12-month life-table continuation rates of 80.6 (SE 1.9)% vs. 83.4 (SE 1.8)% were alike. Cu IUD users discontinued the current method more often because of problems of bleeding and unwanted pregnancy. Among those women who had previously discontinued a hormonal method because of hormonal side effects, there were no differences in the continuation rates of the two groups.

Conclusions: LNg IUS can be successfully used by women who cannot use a CU IUD or who have experienced hormonal side effects with oral contraceptives.

左炔诺孕酮宫内释放系统的选择与性能。
背景:左炔诺孕酮释放宫内系统(LNg IUS)是一种用于宫腔的激素避孕药。为了确定选择LNg IUS和铜释放宫内节育器(Cu iud)的原因是否不同,以及它们的性能是否具有可比性,我们在芬兰进行了LNg IUS使用的第一年的回顾性研究。方法:回顾626例LNg IUS和626 Cu宫内节育器使用者的妇科和避孕史以及节育器的性能。结果:接受LNg IUD的女性比接受Cu IUD的女性更有可能有6天或更长时间的月经出血史(44.4%比28.4%),大出血(44.8%比8.4%)和中度或重度痛经(15.9%比7.5%)。在两组中,70%的妇女都曾使用过宫内节育器。然而,LNg iud受体在以前使用CU iud期间有更多的副作用(58.2%对28.8%)。他们还报告了更多的副作用,导致先前的Cu宫内节育器停止使用(39.4%对10.1%)。然而,12个月生命表延续率分别为80.6 (SE 1.9)%和83.4 (SE 1.8)%。由于出血和意外怀孕的问题,宫内节育器使用者经常停止使用目前的方法。在那些之前因激素副作用而停止激素治疗的妇女中,两组的继续率没有差异。结论:LNg IUS可成功用于不能使用CU IUD或口服避孕药有激素副作用的妇女。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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