[The limitation of acute hypotension and hyperactivation of the vascular endothelium in rats with an experimental myocardial infarct by using preliminary adaptation to physical load].

Abstract

Adaptation to swimming exercise was shown to increase the endothelium-dependent relaxation of the rat aorta, leaving the BP unaffected. In experimental myocardial infarction, the adaptation limited the BP fall and completely prevented an excessive suppression of norepinephrine-induced contractions of the aorta. An adaptation to exercise seems to be an efficient protective factor in pathological conditions involving the NO overproduction and endothelial hyperactivation.