Circadian rhythm of serum erythropoietin in healthy subjects.

Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques Pub Date : 1996-05-01

P Pasqualetti, R Casale

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Abstract

Background: The diurnal rhythm in the circulating serum levels of erythropoietin (EPO) was investigated in healthy subjects.

Methods: Venous blood samples were drawn during the span of a whole day every four hours, starting from midnight, for the determination of serum Epo levels by RIA in 40 clinically healthy normocytemic subjects, 27 males and 13 females, aged 30-75 years. Statistical analysis was carried out by means of the "cosinor" method.

Results: Serum EPO presents a significant (p < 0.05) circadian rhythm with higher levels in the afternoon and lower levels in the nightime.

Conclusions: These data confirm the presence of a circadian rhythm in serum EPO levels. The mechanisms behind the circadian rhythmicity are still unknown. For clinical evaluation of the serum EPO values, the time of day for collection of blood samples has to be taken into consideration.

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健康受试者血清促红细胞生成素的昼夜节律。

背景:研究健康人循环血清促红细胞生成素(EPO)水平的昼夜节律。方法:选取40例30 ~ 75岁临床健康正常细胞者，男27例，女13例，从午夜开始，每隔4小时抽取一天静脉血，采用RIA法测定血清Epo水平。采用余弦法进行统计分析。结果:血清EPO表现出明显的昼夜节律(p < 0.05)，下午较高，夜间较低。结论:这些数据证实血清EPO水平存在昼夜节律。昼夜节律背后的机制尚不清楚。临床评价血清EPO值时，必须考虑采集血样的时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques

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