Elimination of beta-hexachlorocyclohexane in occupationally exposed persons.

Journal of toxicology and environmental health Pub Date : 1997-05-01 DOI:10.1080/00984109708984009

D Jung, H Becher, L Edler, D Flesch-Janys, P Gurn, J Konietzko, A Manz, O Päpke

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引用次数: 56

Abstract

The elimination of beta-hexachlorocyclohexane (beta-HCH) in humans was investigated in a group of 40 former workers of a lindane-producing plant by analyzing at least 2 blood specimens (3 specimens in 3 workers) from different time points. Assuming a first-order kinetic model for excretion, the median half-life of beta-HCH is 7.2 yr calculated by concentrations in whole blood and 7.6 yr calculated by concentrations in extractable lipids. In univariate analyses an influence of age, percent body fat, and liver disease (additionally in whole blood an influence of contents of extractable lipids) on clearance was observed. All factors show a positive correlation with half-life. According to a multiple regression model, influence of percent body fat calculated according to Deurenberg et al. (1991) is an important covariate in the description of the variations of the clearance rate (calculated on the basis of extractable lipids) of beta-HCH. The data support the assumption of first-order kinetics.

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消除职业接触者的-六氯环己烷。

通过分析来自不同时间点的至少2份血液样本(3名工人的3份样本)，对一家林丹生产厂的40名前工人进行了乙型六氯环己烷(乙型hch)在人体中的消除情况进行了调查。假设排泄的一级动力学模型，按全血浓度计算-六氯环己烷的中位半衰期为7.2年，按可提取脂质浓度计算为7.6年。在单变量分析中，观察到年龄、体脂百分比和肝脏疾病(另外，在全血中，可提取脂质含量的影响)对清除率的影响。各因素均与半衰期呈正相关。根据多元回归模型，Deurenberg et al.(1991)计算的体脂百分比的影响是描述乙型六氯环己烷清除率(基于可提取脂质计算)变化的重要协变量。这些数据支持一级动力学的假设。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of toxicology and environmental health

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