Repression of the 5-lipoxygenase gene by c-myb overexpression in differentiated HL-60 cells

Abstract

This paper reports on the involvement of c-MYB in the regulation of 5-lipoxygenase gene expression during differentiation of human HL-60 cells. We demonstrate that c-MYB binds, the 5-lipoxygenase promoter in undifferentiated cells but not in DMSQ-diif ferentiated cells. Also, we show that overexpression of c-myb cDNA in differentiated HL-60 cells represses the 5-lipoxygenase gene expression.