[Shelf-life estimation of pharmaceutical products by matrixing].

S Yoshioka, Y Aso, S Kojima
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Abstract

The shelf-life estimates of pharmaceutical products obtained by matrixing are compared with those obtained by ordinary analysis, using stability data generated by the Monte Carlo method. The effect of the variation in stability due to different packaging and formulations on the shelf-life estimates is described. Analysis of variance is proposed for the evaluation of shelf-life estimates obtained by matrixing. The relationship between the power of the test and the significance level is discussed as well as the effect of assay error on the power of test.

[用矩阵法估计药品的保质期]。
利用蒙特卡罗法生成的稳定性数据,将矩阵法得到的药品保质期估计与普通分析法得到的保质期估计进行了比较。描述了由于不同包装和配方对保质期估计的稳定性变化的影响。采用方差分析方法对矩阵法估计的货架期进行评价。讨论了检验功效与显著性水平之间的关系以及分析误差对检验功效的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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