Amelia P. Guevara , Evangeline Amor , Graeme Russell
{"title":"Antimutagens from Plumeria acuminata Ait","authors":"Amelia P. Guevara , Evangeline Amor , Graeme Russell","doi":"10.1016/S0165-1161(96)90240-X","DOIUrl":null,"url":null,"abstract":"<div><p>Four isolates, <strong>A<sub>1</sub></strong>, <strong>C<sub>1</sub></strong>, <strong>D<sub>3</sub></strong>, and <strong>F<sub>2</sub></strong>, from the ethanol extract of the green leaves of <em>Plumeria acuminata</em> Ait. showed antimutagenic activity. The antimutagens were isolated from he bioactive hexane and carbon tetrachloride fractions</p><p>Four isolates, <strong>A<sub>1</sub></strong>, <strong>C<sub>1</sub></strong>, <strong>D<sub>3</sub></strong>, and <strong>F<sub>2</sub></strong>, from the ethanol extract of the green leaves of <em>Plumeria acuminata</em> Ait. showed antimutagenic activity. The antimutagens were isolated from the bioactive hexane and carbon tetrachloride fractions following a bioactivity-directed fractionation scheme and using the micronucleus test to monitor the antimutagenic activities. Structure elucidation studies indicated that <strong>C<sub>1</sub></strong> is stigmast-7-enol [1], <strong>D<sub>3</sub></strong> is lupeol carboxylic acid [2] and <strong>F<sub>2</sub></strong> is ursolic acid [3]. The structure of <strong>A<sub>1</sub></strong> was not fully elucidated but MS data suggested that it contained a long hydrocarbon chain. At a dosage of 2 mg isolate/25 g mouse, <strong>A<sub>1</sub></strong> reduced the number of micronucleated polychromatic erythrocytes (MPCE) induced by the mutagen, mitomycin C, by 75%, <strong>C<sub>1</sub></strong> by 80%, <strong>D<sub>3</sub></strong> by 57%, and <strong>F<sub>2</sub></strong> by 76%. Compound <strong>A<sub>2</sub></strong> was also isolated but was found inactive. Its structure was identified to be lupeol acetate [4].</p></div>","PeriodicalId":18870,"journal":{"name":"Mutation Research\\/environmental Mutagenesis and Related Subjects","volume":"361 2","pages":"Pages 67-72"},"PeriodicalIF":0.0000,"publicationDate":"1996-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0165-1161(96)90240-X","citationCount":"43","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research\\/environmental Mutagenesis and Related Subjects","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016511619690240X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 43
Abstract
Four isolates, A1, C1, D3, and F2, from the ethanol extract of the green leaves of Plumeria acuminata Ait. showed antimutagenic activity. The antimutagens were isolated from he bioactive hexane and carbon tetrachloride fractions
Four isolates, A1, C1, D3, and F2, from the ethanol extract of the green leaves of Plumeria acuminata Ait. showed antimutagenic activity. The antimutagens were isolated from the bioactive hexane and carbon tetrachloride fractions following a bioactivity-directed fractionation scheme and using the micronucleus test to monitor the antimutagenic activities. Structure elucidation studies indicated that C1 is stigmast-7-enol [1], D3 is lupeol carboxylic acid [2] and F2 is ursolic acid [3]. The structure of A1 was not fully elucidated but MS data suggested that it contained a long hydrocarbon chain. At a dosage of 2 mg isolate/25 g mouse, A1 reduced the number of micronucleated polychromatic erythrocytes (MPCE) induced by the mutagen, mitomycin C, by 75%, C1 by 80%, D3 by 57%, and F2 by 76%. Compound A2 was also isolated but was found inactive. Its structure was identified to be lupeol acetate [4].
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
