S Lange, J Riggert, A Humpe, J Dittmann, G Simson, M Köhler
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引用次数: 0
Abstract
The effects of blood transfusion and blood donation on the immune system are still unclear. In a prospective study we investigated the effect of blood and blood component donation on several immunologic parameters. Lymphocyte subsets and cytokine levels were determined in 25 repeat whole-blood donors (RD), 25 plateletpheresis donors (PD), and 20 autologous blood donors (AD). First-time donors (FTD, n = 20) served as controls. Lymphocyte subsets and cytokines were determined using standard methods. Leukocytes, T-suppressor cells and natural killer (NK) cells were decreased in RD and PD when compared to FTD. Additionally, NK cells decreased with repeat donations in AD. No significant differences of cytokines in the different groups or during repeat autologous donations were observed.
输血和献血对免疫系统的影响尚不清楚。在一项前瞻性研究中，我们调查了血液和血液成分捐献对几个免疫参数的影响。在25例重复全血献血者(RD)、25例血小板献血者(PD)和20例自体献血者(AD)中测定淋巴细胞亚群和细胞因子水平。首次献血者(FTD, n = 20)作为对照组。采用标准方法测定淋巴细胞亚群和细胞因子。与FTD相比，RD和PD的白细胞、t抑制细胞和自然杀伤细胞(NK)减少。此外，在AD患者中，NK细胞随着重复捐赠而减少。细胞因子在不同组和重复自体捐献期间无显著差异。
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