Clinical neuroimmunology

Advances in neuroimmunology Pub Date : 1996-01-01 DOI:10.1016/S0960-5428(96)00020-4

Xian-hao Xu, Hua Zhang, Hong Guo, Xiu-yun Wang, Hong Sun, Xiong Han, Bao-lin Li, Feng-zhen Pang, Hong Wang, Shi-Guang Wen, Yun Jiang, Min-xun Tan

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Abstract

Clinical research has focused on autoimmune disease (AID) for a couple of decades. More sensitive and specific methods have been developed for neuroimmunological research. Gamma fraction bands (bands separated by electrophoresis and visualized by amino black staining) and IgG fraction bands (bands separated by iso-electric focusing and visualized by immunostaining) are used instead of oligoclonal bands. Myasthenia gravis (MG) mainly involves acetylcholine receptors of the postsynaptic membrane at the neuromuscular junction. Myasthenia gravis has been considered to be a generalized AID, because 7% of patients with myasthenia gravis associate with other AIDs and more than one autoimmune antibody is detected in 52.5% patients with myasthenia gravis. Pyramidal signs in myasthenia gravis patients are described; the possible mechanism may at least be partly due to the acetylcholine receptor antibody. P2 protein and its antibody are studied in patients with acute and chronic inflammatory demyelinating polyneuropathy.

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临床神经免疫学

几十年来，临床研究一直关注自身免疫性疾病(AID)。神经免疫学研究已经发展出更敏感和特异的方法。使用γ片段带(通过电泳分离并通过氨基黑染色显示)和IgG片段带(通过等电聚焦分离并通过免疫染色显示)代替寡克隆带。重症肌无力主要与神经肌肉连接处突触后膜的乙酰胆碱受体有关。重症肌无力被认为是一种广泛性艾滋病，因为7%的重症肌无力患者伴有其他艾滋病，52.5%的重症肌无力患者检测到一种以上的自身免疫抗体。描述重症肌无力患者的锥体征象;可能的机制至少部分是由于乙酰胆碱受体抗体。研究急慢性炎性脱髓鞘性多发性神经病患者P2蛋白及其抗体的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in neuroimmunology

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