Turning behavior in rats with unilateral lesions of the subthalamic nucleus: synergism between D1 and D2 receptors.

Journal of neural transmission. General section Pub Date : 1995-01-01 DOI:10.1007/BF01271535

M G Murer, V Sinay, J H Pazo

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引用次数: 3

Abstract

Rats with unilateral kainic acid lesion of the subthalamic nucleus showed a dose dependent rotational response to the lesioned side (ipsilateral) after systemic administration of the non-selective dopaminergic agonist apomorphine. Both D2 and D1 selective antagonists ((-)sulpiride and SCH23390) inhibited the response to apomorphine in these rats. Selective D2 and D1 agonists (quinpirole and SKF38393) were unable to induce turning behavior. However, an ipsilateral circling response was obtained after the simultaneous application of both agonists. The interaction mechanism between dopaminergic receptor subtypes seems to be similar to that of other normosensitive models of turning previously studied (Barone et al., 1986; Robertson and Robertson, 1986; Arnt and Perregard, 1987; Asim et al., 1990; Pazo et al., 1993). It is proposed that the ipsilateral turning response to dopaminergic agonists in rats with subthalamic nucleus lesion results from an impaired behavioral expression of the action of dopaminergic agonists on one side, leading the rats to turn away from the intact hemisphere.

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丘脑下核单侧病变大鼠的转身行为:D1和D2受体之间的协同作用。

大鼠单侧丘脑底核kainic酸损伤，在全身给予非选择性多巴胺能激动剂阿波啡后，显示出对损伤侧(同侧)的剂量依赖性旋转反应。D2和D1选择性拮抗剂((-)舒必利和SCH23390)抑制了这些大鼠对阿波啡的反应。选择性D2和D1激动剂(喹匹罗和SKF38393)不能诱导转向行为。然而，在两种激动剂同时应用后，获得了同侧圆反应。多巴胺能受体亚型之间的相互作用机制似乎与先前研究的其他正常敏感的转向模型相似(Barone et al.， 1986;Robertson and Robertson, 1986;Arnt and Perregard, 1987;Asim等人，1990;Pazo等人，1993)。我们认为，丘脑下核损伤大鼠对多巴胺能激动剂的同侧转向反应是由于一侧多巴胺能激动剂作用的行为表达受损，导致大鼠从完整的半球转向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of neural transmission. General section

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