Free to total prostate-specific antigen (PSA) ratio is superior to total-PSA in differentiating benign prostate hypertrophy from prostate cancer.

The Prostate. Supplement Pub Date : 1996-01-01

P J Van Cangh, P De Nayer, P Sauvage, B Tombal, M Elsen, F Lorge, R Opsomer, F X Wese

{"title":"Free to total prostate-specific antigen (PSA) ratio is superior to total-PSA in differentiating benign prostate hypertrophy from prostate cancer.","authors":"P J Van Cangh, P De Nayer, P Sauvage, B Tombal, M Elsen, F Lorge, R Opsomer, F X Wese","doi":"","DOIUrl":null,"url":null,"abstract":"Background: Serum prostate-specific antigen (PSA) exists in different molecular forms, and their respective concentration has been proposed as a useful tool to improve discrimination between benign prostatic hypertrophy (BPH) and prostate cancer (PC).Methods: The relevance of the free to total PSA ratio was prospectively studied in a selected urology clinic population of 420 patients. Total serum PSA ranged from 2.1 to 30 ng/ml; 154 had PC and 266 had BPH.Results: Receiver operating characteristic (ROC) curves were constructed for the total population (total-PSA range from 2.1 to 30 ng/ml) and for the diagnostic gray zone of 2.1-10 ng/ml. For the two groups, the free to total PSA ratio had a higher specificity than total-PSA for all sensitivity levels. Cut-off values were found to, vary with prostate weight.Conclusions: Although free to total PSA ratio demonstrated better performances than total-PSA, its use in screening appears problematic, due to the low prevalence of prostate cancer.","PeriodicalId":77436,"journal":{"name":"The Prostate. Supplement","volume":"7 ","pages":"30-4"},"PeriodicalIF":0.0000,"publicationDate":"1996-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Prostate. Supplement","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Serum prostate-specific antigen (PSA) exists in different molecular forms, and their respective concentration has been proposed as a useful tool to improve discrimination between benign prostatic hypertrophy (BPH) and prostate cancer (PC).

Methods: The relevance of the free to total PSA ratio was prospectively studied in a selected urology clinic population of 420 patients. Total serum PSA ranged from 2.1 to 30 ng/ml; 154 had PC and 266 had BPH.

Results: Receiver operating characteristic (ROC) curves were constructed for the total population (total-PSA range from 2.1 to 30 ng/ml) and for the diagnostic gray zone of 2.1-10 ng/ml. For the two groups, the free to total PSA ratio had a higher specificity than total-PSA for all sensitivity levels. Cut-off values were found to, vary with prostate weight.

Conclusions: Although free to total PSA ratio demonstrated better performances than total-PSA, its use in screening appears problematic, due to the low prevalence of prostate cancer.

本刊更多论文

游离与总前列腺特异性抗原(PSA)比值在鉴别前列腺肥大与前列腺癌方面优于总PSA。

背景:血清前列腺特异性抗原(PSA)以不同的分子形式存在，其各自的浓度已被提出作为提高良性前列腺肥大(BPH)和前列腺癌(PC)鉴别的有用工具。方法:对420例泌尿外科门诊患者的游离PSA与总PSA比值的相关性进行前瞻性研究。血清总PSA为2.1 ~ 30 ng/ml;PC 154例，BPH 266例。结果:构建了总体(总psa范围为2.1 ~ 30 ng/ml)和诊断灰色区域2.1 ~ 10 ng/ml的受试者工作特征(ROC)曲线。对于两组，游离PSA与总PSA的比值在所有敏感性水平上都比总PSA具有更高的特异性。临界值随前列腺重量的变化而变化。结论:尽管游离与总PSA比表现出比总PSA更好的性能，但由于前列腺癌的低患病率，其在筛查中的应用存在问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

The Prostate. Supplement

自引率

0.00%

发文量