Effects of estrogen and progesterone on plasma platelet-activating factor-acetylhydrolase activity and low-density lipoprotein cholesterol concentration in men.

Artery Pub Date : 1996-01-01

A Ohshige, M Ito, H Koyama, T Maeda, T Yoshimura, H Okamura

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Abstract

Objective: We examined the effects of estrogen and progesterone on the plasma platelet-activating factor (PAF)-acetylhydrolase activity and lipoprotein concentrations in men.

Method: Ten healthy men received 6 days of oral mestranol (0.24 mg/day) followed by 6 days of oral norethisterone (20 mg/day). The PAF-acetylhydrolase activity and lipoprotein profiles were determined in each subject prior to and following mestranol loading and following norethisterone administration.

Result: The mestranol caused a significant decrease in both the plasma PAF-acetylhydrolase activity and the low-density lipoprotein (LDL) cholesterol concentrations of 26.4% and 26.9%, respectively; norethisterone appeared to revert the PAF-acetylhydrolase activity and LDL cholesterol concentrations to the levels observed prior to mestranol loading. In addition, the plasma PAF-acetylhydrolase activity was positive correlated with the LDL cholesterol concentration (r = 0.58, P < 0.001).

Conclusion: The results of this study indicate that mestranol and norethisterone exert an effect on the plasma PAF-acetylhydrolase activity in men, possibly by influencing plasma LDL cholesterol concentrations.

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雌激素和黄体酮对男性血浆血小板活化因子-乙酰水解酶活性和低密度脂蛋白胆固醇浓度的影响。

目的:探讨雌激素和黄体酮对男性血浆血小板活化因子乙酰水解酶活性和脂蛋白浓度的影响。方法:健康男性10例，口服美雌醇(0.24 mg/d) 6 d，口服去甲睾酮(20 mg/d) 6 d。在每个受试者中，在装载美雌醇之前和之后以及给药去甲睾酮之后，测定了paf -乙酰水解酶活性和脂蛋白谱。结果:mestranol使大鼠血浆paf -乙酰水解酶活性和低密度脂蛋白(LDL)胆固醇浓度分别下降26.4%和26.9%;去甲睾酮似乎将paf -乙酰水解酶活性和低密度脂蛋白胆固醇浓度恢复到装载mestranol之前的水平。血浆paf -乙酰水解酶活性与LDL胆固醇浓度呈正相关(r = 0.58, P < 0.001)。结论:本研究结果表明，美雌醇和去甲睾酮可能通过影响血浆LDL -胆固醇浓度对男性血浆paf -乙酰水解酶活性产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Artery

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