{"title":"Seasonal cutaneous immune responses in an Antarctic wintering group: no association with testosterone, vitamin D metabolite or anxiety score.","authors":"G A Pitson, D J Lugg, H K Muller","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Immune function is modulated by a complex set of neuroendocrine factors including sex hormones, vitamin D metabolites and stress. Antarctic expeditioners exhibit reduced cell mediated immunity. Studies have also shown a reduction in testosterone levels in wintering expeditioners and suggested a correlation between levels of anxiety and reduced immune function in brief trip expeditioners. Nineteen male Antarctic expeditioners were followed by 3 monthly assessments of cell mediated immunity, levels of testosterone and vitamin D metabolite and psychological indicators of anxiety. There was a significant reduction in immune function during the study period, consistent with previous Antarctic studies. Levels of testosterone, anxiety and the immunoregulatory metabolite of vitamin D did not alter significantly. In this group the reduction in immune function did not show a correlation with levels of anxiety or the hormones studied.</p>","PeriodicalId":77012,"journal":{"name":"Arctic medical research","volume":"55 3","pages":"118-22"},"PeriodicalIF":0.0000,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arctic medical research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Immune function is modulated by a complex set of neuroendocrine factors including sex hormones, vitamin D metabolites and stress. Antarctic expeditioners exhibit reduced cell mediated immunity. Studies have also shown a reduction in testosterone levels in wintering expeditioners and suggested a correlation between levels of anxiety and reduced immune function in brief trip expeditioners. Nineteen male Antarctic expeditioners were followed by 3 monthly assessments of cell mediated immunity, levels of testosterone and vitamin D metabolite and psychological indicators of anxiety. There was a significant reduction in immune function during the study period, consistent with previous Antarctic studies. Levels of testosterone, anxiety and the immunoregulatory metabolite of vitamin D did not alter significantly. In this group the reduction in immune function did not show a correlation with levels of anxiety or the hormones studied.