Seasonal cutaneous immune responses in an Antarctic wintering group: no association with testosterone, vitamin D metabolite or anxiety score.

Arctic medical research Pub Date : 1996-07-01
G A Pitson, D J Lugg, H K Muller
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Abstract

Immune function is modulated by a complex set of neuroendocrine factors including sex hormones, vitamin D metabolites and stress. Antarctic expeditioners exhibit reduced cell mediated immunity. Studies have also shown a reduction in testosterone levels in wintering expeditioners and suggested a correlation between levels of anxiety and reduced immune function in brief trip expeditioners. Nineteen male Antarctic expeditioners were followed by 3 monthly assessments of cell mediated immunity, levels of testosterone and vitamin D metabolite and psychological indicators of anxiety. There was a significant reduction in immune function during the study period, consistent with previous Antarctic studies. Levels of testosterone, anxiety and the immunoregulatory metabolite of vitamin D did not alter significantly. In this group the reduction in immune function did not show a correlation with levels of anxiety or the hormones studied.

南极越冬组的季节性皮肤免疫反应:与睾酮、维生素D代谢物或焦虑评分无关
免疫功能受到一系列复杂的神经内分泌因素的调节,包括性激素、维生素D代谢物和压力。南极探险者表现出细胞介导的免疫力下降。研究还表明,冬季探险者的睾丸激素水平降低,并表明短途探险者的焦虑水平与免疫功能下降之间存在相关性。对19名男性南极探险者进行了为期3个月的细胞免疫、睾酮和维生素D代谢物水平以及焦虑心理指标评估。在研究期间,免疫功能显著下降,这与之前的南极研究一致。睾酮、焦虑和维生素D免疫调节代谢物的水平没有显著变化。在这一组中,免疫功能的下降与焦虑水平或所研究的激素没有相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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