Kaposi's Sarcoma (KS)-associated herpesvirus and its role in KS.

Infectious agents and disease Pub Date : 1996-10-01
Y Chang, P S Moore
{"title":"Kaposi's Sarcoma (KS)-associated herpesvirus and its role in KS.","authors":"Y Chang,&nbsp;P S Moore","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Epidemiologic studies have long suggested that Kaposi's sarcoma (KS) is caused by a sexually transmissible infectious agent. A new, and presumably human, herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), has been detected in KS lesions from AIDS patients by sequence-based detection techniques. KSHV is present in almost all KS lesions from all forms of KS. The virus is a Rhadinovirus or gamma-2 herpesvirus most closely related to Herpesvirus saimiri (HVS), and possesses several genes that may allow it to modify its host cell environment. KSHV has been isolated in vitro with immortalized B cell lines derived from a second malignancy associated with KSHV, body cavity-based lymphomas (BCBL). Epidemiologic studies performed to date indicate that KSHV, unlike other human herpesviruses (HHV), is not ubiquitous. The growing body of evidence indicates that KSHV is a potent oncogenic herpesvirus and the likely infectious cause of KS and BCBL.</p>","PeriodicalId":77176,"journal":{"name":"Infectious agents and disease","volume":"5 4","pages":"215-22"},"PeriodicalIF":0.0000,"publicationDate":"1996-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious agents and disease","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Epidemiologic studies have long suggested that Kaposi's sarcoma (KS) is caused by a sexually transmissible infectious agent. A new, and presumably human, herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), has been detected in KS lesions from AIDS patients by sequence-based detection techniques. KSHV is present in almost all KS lesions from all forms of KS. The virus is a Rhadinovirus or gamma-2 herpesvirus most closely related to Herpesvirus saimiri (HVS), and possesses several genes that may allow it to modify its host cell environment. KSHV has been isolated in vitro with immortalized B cell lines derived from a second malignancy associated with KSHV, body cavity-based lymphomas (BCBL). Epidemiologic studies performed to date indicate that KSHV, unlike other human herpesviruses (HHV), is not ubiquitous. The growing body of evidence indicates that KSHV is a potent oncogenic herpesvirus and the likely infectious cause of KS and BCBL.

卡波西肉瘤(KS)相关疱疹病毒及其在KS中的作用。
流行病学研究早就表明卡波西肉瘤(KS)是由性传播感染因子引起的。一种新的,可能是人类的疱疹病毒,卡波西肉瘤相关疱疹病毒(KSHV/HHV-8),已经通过基于序列的检测技术在艾滋病患者的KS病变中检测到。KSHV几乎存在于所有形式的KS病变中。该病毒是一种与猴疱疹病毒(HVS)最密切相关的rhadinvirus或γ -2 herpesvirus,它拥有几个可以改变宿主细胞环境的基因。KSHV已经在体外用来自与KSHV相关的第二种恶性肿瘤——体腔淋巴瘤(BCBL)的永生化B细胞系分离出来。迄今为止进行的流行病学研究表明,与其他人类疱疹病毒(HHV)不同,KSHV并非普遍存在。越来越多的证据表明,KSHV是一种强效的致癌疱疹病毒,可能是KS和BCBL的感染原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信