{"title":"Kaposi's Sarcoma (KS)-associated herpesvirus and its role in KS.","authors":"Y Chang, P S Moore","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Epidemiologic studies have long suggested that Kaposi's sarcoma (KS) is caused by a sexually transmissible infectious agent. A new, and presumably human, herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), has been detected in KS lesions from AIDS patients by sequence-based detection techniques. KSHV is present in almost all KS lesions from all forms of KS. The virus is a Rhadinovirus or gamma-2 herpesvirus most closely related to Herpesvirus saimiri (HVS), and possesses several genes that may allow it to modify its host cell environment. KSHV has been isolated in vitro with immortalized B cell lines derived from a second malignancy associated with KSHV, body cavity-based lymphomas (BCBL). Epidemiologic studies performed to date indicate that KSHV, unlike other human herpesviruses (HHV), is not ubiquitous. The growing body of evidence indicates that KSHV is a potent oncogenic herpesvirus and the likely infectious cause of KS and BCBL.</p>","PeriodicalId":77176,"journal":{"name":"Infectious agents and disease","volume":"5 4","pages":"215-22"},"PeriodicalIF":0.0000,"publicationDate":"1996-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious agents and disease","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Epidemiologic studies have long suggested that Kaposi's sarcoma (KS) is caused by a sexually transmissible infectious agent. A new, and presumably human, herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8), has been detected in KS lesions from AIDS patients by sequence-based detection techniques. KSHV is present in almost all KS lesions from all forms of KS. The virus is a Rhadinovirus or gamma-2 herpesvirus most closely related to Herpesvirus saimiri (HVS), and possesses several genes that may allow it to modify its host cell environment. KSHV has been isolated in vitro with immortalized B cell lines derived from a second malignancy associated with KSHV, body cavity-based lymphomas (BCBL). Epidemiologic studies performed to date indicate that KSHV, unlike other human herpesviruses (HHV), is not ubiquitous. The growing body of evidence indicates that KSHV is a potent oncogenic herpesvirus and the likely infectious cause of KS and BCBL.