Determinants of Helicobacter pylori pathogenicity.

Infectious agents and disease Pub Date : 1996-10-01
A Labigne, H de Reuse
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引用次数: 0

Abstract

Helicobacter pylori is a recently recognized bacterial pathogen associated with diverse pathologies of varying severity, such as chronic gastritis, peptic ulceration, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric carcinoma. We here present a review of our current knowledge on the properties of H. Pylori that adapt it to its particular niche by allowing it to survive in the stomach and to colonize the gastric mucosa, as well as those that underlie its persistence and pathogenicity. While the bacterial determinants that preclude the persistent colonization of the gastric mucosa are better understood, those associated with pathogenicity appear to result from the possibility for some of the bacteria of the species to synthesize products that directly or indirectly damage the gastric mucosa, cause a persistent inflammatory reaction, and/or perturb the regulation of acid secretion.

幽门螺杆菌致病性的决定因素。
幽门螺杆菌是最近发现的一种细菌性病原体,与多种不同严重程度的病理相关,如慢性胃炎、消化性溃疡、粘膜相关淋巴组织淋巴瘤和胃癌。在此,我们对幽门螺杆菌的特性进行了综述,这些特性使幽门螺杆菌能够在胃中生存并在胃粘膜上定植,从而适应其特定的生态位,同时也对其持久性和致病性进行了综述。虽然对阻止胃黏膜持续定植的细菌决定因素有了更好的了解,但那些与致病性相关的因素似乎是由于该物种的一些细菌可能合成直接或间接损害胃黏膜的产物,引起持续的炎症反应,和/或扰乱酸分泌的调节。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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