Metabolic effects of the combination of furosemide and captopril in rat.

Revista espanola de fisiologia Pub Date : 1996-06-01
R López, C Taboada, C Rivas, A San Miguel
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Abstract

Diuretics typically provoke increased serum lipid levels and may provoke increased serum uric acid levels and/or glucose intolerance. Furosemide is widely used as an antihypertensive, but in patients for whom furosemide treatment alone proves insufficient to reduce hypertension, a common procedure is to co-administer the angiotensin-converting-enzyme (ACE) inhibitor captopril. The metabolic effects in rats of joint administration of furosemide (15 mg/kg/day) and captopril (2 mg/kg/day) are evaluated over a two-week period. At the end of this period, the serum levels of lipids, uric acid, bilirubin, proteins and various enzymes were determined as well as the effect of the treatment on intestinal absorption of glucose and calcium. Furosemide/captopril led to an increase in serum albumin and alkaline phosphatase levels, and a decrease in triglyceride levels. The results of this work support the view that this drug combination is suitable for hypertension treatment.

速尿与卡托普利联用对大鼠代谢的影响。
利尿剂通常引起血脂水平升高,并可能引起血清尿酸水平升高和/或葡萄糖耐受不良。呋塞米被广泛用作降压药,但对于那些单独呋塞米治疗不足以降低高血压的患者,一种常见的治疗方法是联合使用血管紧张素转换酶(ACE)抑制剂卡托普利。联合给药呋塞米(15mg /kg/天)和卡托普利(2mg /kg/天)对大鼠的代谢影响进行了为期两周的评估。试验结束后,测定血清血脂、尿酸、胆红素、蛋白质及各种酶的水平,以及治疗对肠道葡萄糖和钙吸收的影响。速尿/卡托普利导致血清白蛋白和碱性磷酸酶水平升高,甘油三酯水平降低。本研究结果支持该药物组合适合高血压治疗的观点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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