[A 28-day repeated dose toxicity test of Phoxim in Wistar rats].

S Suzuki, Y Ogawa, E Kamata, K Naito, T Umemura, M Saito, T Kaneko, Y Kurokawa
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引用次数: 0

Abstract

A 28-day oral toxicity test of Phoxim was carried out in male and female Slc: Wistar rats given dose levels of 0, 7.5, 75 and 750 mg/kg/day by gavage. A 14-day recovery test was conducted for animals receiving the 750 mg/kg dose level. There were no deaths with any dose and food consumption and growth were not affected. No specific changes were observed in any of the hematological parameters investigated. At the 750 mg/kg level, significant increases of liver, kidney, and adrenal gland weights were observed in both sexes, which persisted throughout the recovery period. Hepatic lesions with necrosis and swelling of hepatocytes were also observed with the highest dose, but these changes appeared to be reversible because they were no longer present after the recovery period. At doses of 7.5 mg/kg and above, remarkable inhibition of the serum cholinesterase activity was observed in both sexes. This persisting in female rats after the recovery period. Based on these results, the no-observed-effect level (NOEL) was concluded to be less than 7.5 mg/kg/day under the present experimental conditions.

[Wistar大鼠硫辛硫磷28天重复给药毒性试验]。
以0、7.5、75、750mg /kg/d灌胃给药,对雄性和雌性Slc: Wistar大鼠进行了28天的口服毒性试验。接受750 mg/kg剂量水平的动物进行了14天的恢复试验。没有任何剂量的死亡,食物消耗和生长也没有受到影响。没有观察到任何血液学参数的特殊变化。在750 mg/kg水平下,两性肝脏、肾脏和肾上腺重量显著增加,并持续整个恢复期。在最高剂量下也观察到肝细胞坏死和肿胀的肝脏病变,但这些变化似乎是可逆的,因为它们在恢复期后不再存在。在7.5 mg/kg及以上的剂量下,两性血清胆碱酯酶活性均被显著抑制。这种情况在恢复期后的雌性大鼠中持续存在。根据上述结果,在本实验条件下,无观察效应水平(NOEL)小于7.5 mg/kg/day。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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