Regulation of IGFBP-1 in humans

Abstract

IGFBP-1 secretion in humans is regulated by insulin and the counter-regulatory hormones with a high production rate and rapid turnover. The IGFBP-1 fasting levels are both genetically and environmentally determined. Serum IGFBP-1 levels may be regulated by so far unknown factors during certain conditions. The fasting IGFBP-1 level can be used as a marker of diurnal IGFBP-1 and insulin secretion.