MMP-2: expression, activation and inhibition.

Enzyme & protein Pub Date : 1996-01-01 DOI:10.1159/000468613
M L Corcoran, R E Hewitt, D E Kleiner, W G Stetler-Stevenson
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引用次数: 206

Abstract

Remodeling of the extracellular matrix (ECM), which occurs during many physiological and pathological processes, is one of the requisite events of cellular invasion. The matrix metalloproteinases (MMPs) are a family of zinc-dependent proteases that are responsible for proteolytic degradation of specific ECM components. Regulating the activity of the MMPs at both mRNA and/or protein levels modulates the degradation of the ECM components which in turn alter cellular invasion. Although most MMPs are regulated via similar mechanisms at the mRNA and protein levels, the modulation of gelatinase A is unique. Understanding the mechanisms that regulate gelatinase A is important since expression and activation of this particular MMP is consistently correlated with a majority of malignant phenotypes. In this report, we will contrast the mechanisms that regulate the expression, activation and inhibition of gelatinase A with the mechanisms that modulate the rest the MMP family.

MMP-2:表达、激活和抑制。
细胞外基质(ECM)的重构是细胞侵袭的必要事件之一,它发生在许多生理和病理过程中。基质金属蛋白酶(MMPs)是一个依赖锌的蛋白酶家族,负责特定ECM成分的蛋白水解降解。在mRNA和/或蛋白质水平上调节MMPs的活性可以调节ECM成分的降解,从而改变细胞侵袭。虽然大多数MMPs在mRNA和蛋白质水平上通过类似的机制进行调节,但明胶酶A的调节是独特的。了解调节明胶酶A的机制是很重要的,因为这种特殊的MMP的表达和激活始终与大多数恶性表型相关。在本报告中,我们将比较调节明胶酶A的表达、激活和抑制的机制与调节其他MMP家族的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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