Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay ‘unique positive’ NTP carcinogens

Mutation Research/Genetic Toxicology Pub Date : 1996-08-12 DOI:10.1016/S0165-1218(96)90029-4

A. Matsuoka , K. Yamakage , H. Kusakabe , S. Wakuri , M. Asakura , T. Noguchi , T. Sugiyama , H. Shimada , S. Nakayama , Y. Kasahara , Y. Takahashi , K.F. Miura , M. Hatanaka , M. Ishidate Jr. , T. Morita , K. Watanabe , M. Hara , K. Odawara , N. Tanaka , M. Hayashi , T. Sofuni

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引用次数: 55

Abstract

In a collaborative study organized under the JEMS MMS, nine mouse lymphoma assay (MLA) ‘unique positive’ NTP rodent carcinogens were re-evaluated by an in vitro chromosomal aberration assay using Chinese hamster lung fibroblast cells (CHL/IU). Six of nine chemicals induced chromosomal aberrations; bromodichloromethane, chlorendic acid and isophorone induced structural aberrations, and chlorodibromomethane, pentachloromethane and 1,1,1,2-tetrachloroethane induced numerical aberrations (polyploidy). These six chemicals, therefore, are not uniquely positive in the MLA. The difference between the NTP results and ours might be due to the use of diffent cell lines and protocols, and in some cases, to different interpretations of polyploidy. The remaining three chemicals, ebzykl acetate, cinnamyl anthranilate and trichloroethylene, were negative in this study.

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九种小鼠淋巴瘤试验“独特阳性”NTP致癌物对染色体畸变诱导的再评价

在JEMS MMS组织的一项合作研究中，使用中国仓鼠肺成纤维细胞(CHL/IU)进行体外染色体畸变试验，重新评估了9种小鼠淋巴瘤试验(MLA)“独特阳性”NTP啮齿动物致癌物。9种化学物质中有6种诱发染色体畸变;溴二氯甲烷、氯二酸和异弗龙诱导结构像差，氯二溴甲烷、五氯甲烷和1,1,1,2-四氯乙烷诱导数值像差(多倍体)。因此，这六种化学物质在MLA中并不是唯一呈阳性的。国家毒理学计划的结果与我们的结果之间的差异可能是由于使用不同的细胞系和方案，在某些情况下，多倍体的不同解释。其余三种化学物质乙酸乙二酯、肉桂酰苯甲酸酯和三氯乙烯在本研究中均为阴性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mutation Research/Genetic Toxicology

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